
Research progress on copy number alterations in pediatric B-cell acute lymphoblastic leukemia
Xi-Yuan XU, Qun HU
Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (6) : 746-752.
Research progress on copy number alterations in pediatric B-cell acute lymphoblastic leukemia
Copy number alteration (CNA) is a significant genetic change in pediatric B-cell acute lymphoblastic leukemia (B-ALL), with CDKN2A/B deletions, PAX5 deletions, and IKZF1 deletions being the most common. Recent studies have increasingly highlighted the potential prognostic significance of these gene deletions and multiple co-deletions in pediatric B-ALL. This paper reviews the main detection methods for CNA, as well as the prognostic characteristics and treatment approaches for common CNA in pediatric B-ALL.
Acute lymphoblastic leukemia / Copy number alteration / Prognosis / Treatment / Child
1 |
杨文钰, 竺晓凡. 中国儿童急性白血病的诊治现状及展望[J]. 中华医学杂志, 2024, 104(27): 2477-2482. DOI: 10.3760/cma.j.cn112137-20231211-01347 .
|
2 |
|
3 |
|
4 |
|
5 |
|
6 |
|
7 |
|
8 |
|
9 |
|
10 |
|
11 |
|
12 |
|
13 |
|
14 |
|
15 |
|
16 |
|
17 |
|
18 |
|
19 |
|
20 |
|
21 |
|
22 |
|
23 |
|
24 |
|
25 |
|
26 |
|
27 |
|
28 |
|
29 |
|
30 |
|
31 |
|
32 |
|
33 |
|
34 |
|
35 |
|
36 |
|
37 |
|
38 |
|
39 |
|
40 |
|
41 |
|
42 |
|
43 |
|
44 |
|
45 |
|
46 |
|
47 |
|
48 |
|
49 |
|
50 |
|
51 |
|
52 |
|
53 |
|
许喜原综述;胡群审校。