Potential impact of adjusting immunization procedure for diphtheria-tetanus-pertussis vaccine on pertussis in clinical practice

Ya-Hong HU; Kai-Hu YAO

doi:10.7499/j.issn.1008-8830.2501077

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Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (7) : 786-791. DOI: 10.7499/j.issn.1008-8830.2501077

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Potential impact of adjusting immunization procedure for diphtheria-tetanus-pertussis vaccine on pertussis in clinical practice

Ya-Hong HU ,
Kai-Hu YAO

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Abstract

In recent years, the incidence rate of pertussis in China has been steadily increasing, presenting an increasingly severe challenge for disease prevention and control. To strengthen the immune barrier in the population and effectively curb the spread of pertussis, National Disease Control and Prevention Administration of China and other relevant authorities optimized the immunization procedure for diphtheria-tetanus-pertussis vaccine, with the new procedure implemented in 2025. This adjustment includes three key measures: advancing the initial dose of the vaccine from 3 months to 2 months of age, extending the interval between primary immunization doses from 1 month to 2 months, and adding an extra dose of acellular diphtheria-tetanus-pertussis vaccine at 6 years of age. This article discusses potential changes in the epidemiology and clinical manifestations of pertussis following such adjustments for immunization procedure, and awareness of these changes will facilitate the accurate identification of pertussis cases, which is crucial for evaluating the impact of these adjustments and further optimizing immunization strategies.

Key words

Pertussis / Diphtheria-tetanus-pertussis vaccine / Immunization procedure / Epidemiology

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Ya-Hong HU , Kai-Hu YAO. Potential impact of adjusting immunization procedure for diphtheria-tetanus-pertussis vaccine on pertussis in clinical practice[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(7): 786-791 https://doi.org/10.7499/j.issn.1008-8830.2501077

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