Monitoring and interventions of growth disorders and endocrine function in children with transfusion-dependent thalassemia

FAN Xin, HUANG Yi-Yun

Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (4) : 389-394.

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Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (4) : 389-394. DOI: 10.7499/j.issn.1008-8830.2501080
SERIES REVIEW—DIAGNOSIS AND TREATMENT OF GROWTH DISORDERS

Monitoring and interventions of growth disorders and endocrine function in children with transfusion-dependent thalassemia

  • FAN Xin, HUANG Yi-Yun
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Abstract

Transfusion-dependent thalassemia (TDT) is a severe genetic chronic hemolytic disease, and growth retardation is a common clinical feature in patients with TDT. Due to the need for regular blood transfusions, these patients often experience iron overload, which leads to various endocrine dysfunctions, including abnormalities in the growth hormone/insulin-like growth factor axis, hypothyroidism, hypoparathyroidism, hypogonadism, adrenal insufficiency, and decreased bone density. This paper reviews the clinical monitoring and intervention measures for growth disorders and related endocrine functions in patients with TDT, providing references for clinicians.

Key words

Thalassemia / Endocrine dysfunction / Growth and development / Iron overload / Recombinant human growth hormone

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FAN Xin, HUANG Yi-Yun. Monitoring and interventions of growth disorders and endocrine function in children with transfusion-dependent thalassemia[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(4): 389-394 https://doi.org/10.7499/j.issn.1008-8830.2501080

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