Neuropsychological development status and risk factors in small for gestational age infants at corrected ages 12-24 months

Ran TAN, Li-Ya MA, Chang LIU, Qian LYU, Bi-Lan DING, Wan-Xiang XIAO

Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (11) : 1339-1345.

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Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (11) : 1339-1345. DOI: 10.7499/j.issn.1008-8830.2504129
CLINICAL RESEARCH

Neuropsychological development status and risk factors in small for gestational age infants at corrected ages 12-24 months

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Abstract

Objective To explore the status and risk factors of neuropsychological development in small for gestational age (SGA) infants at corrected 12-24 months of age. Methods Clinical data were retrospectively collected for 754 SGA infants at corrected ages 12-24 months in Shenzhen Bao'an Women and Children's Hospital between April 2018 and December 2023. Developmental quotient (DQ) levels were analyzed. According to the presence of global developmental delay (GDD), participants were divided into a GDD group (71 cases) and a control group (683 cases), and the incidence and influencing factors of GDD were investigated. Results In the high-risk preterm SGA group, the total DQ and DQ in all domains were lower than in the full-term SGA group (P<0.017). The overall incidence of GDD was 9.4% (71/754) and increased with decreasing gestational age (P<0.017). Compared with the control group, the GDD group had higher proportions of males; low-risk and high-risk preterm birth; mothers with less than a bachelor's degree; multiple birth; neonatal hypoglycemia; neonatal pneumonia; neonatal respiratory distress syndrome; bronchopulmonary dysplasia; and, at corrected 12-24 months, low body weight, growth retardation, and microcephaly. The length of neonatal hospital stay was longer in the GDD group than in the control group (P<0.05). The weight-for-age Z score, length-for-age Z score, and head circumference-for-age Z score at birth and at corrected 12-24 months were lower in the GDD group than in the control group (P<0.05). Multivariable logistic regression showed that male sex and maternal education below a bachelor's degree were independent risk factors for GDD in SGA infants (P<0.05). Conclusions Neuropsychological development in preterm SGA infants is comparatively delayed; male SGA infants born to mothers with less than a bachelor's degree should receive priority attention.

Key words

Global developmental delay / Neuropsychological development / Developmental quotient / Risk factor / Small for gestational age infant

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Ran TAN , Li-Ya MA , Chang LIU , et al . Neuropsychological development status and risk factors in small for gestational age infants at corrected ages 12-24 months[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(11): 1339-1345 https://doi.org/10.7499/j.issn.1008-8830.2504129

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