Objective To explore Naloxone effect on treating patients with coma through clinical observation of recovery process of the children. Methods 82 children with coma due to various causes were divided into two groups. The control group (n=40) was treated with regular antiinflammation, diuretic, dehydrant, antifebrile and sedatives , while the treatment group (n=42) with Naloxone besides the regular therapy . Results Total effective rate in treatment group was significantly higher than that in control group (59.5% vs. 45%, P<0.05). The in-patient days of treatment group were significantly shorter than of control group (13.7±2.15 d vs. 15.8±2.05 d , P<0.01). Conclusions The finding showed Naloxone was more effective in treating patients with coma and shortened their average days in hospital.