Objective To study the changes of Liopoprotein (a) in 96 children with a family history of either myocardial infarction or cerebrovascular events. Methods Enzyme Linked Immunosorbent Assay(ELISA) was used to determine Lp(a).Results The level of Lp(a) markedly increased in children with a family history of myocardial infarction as compared with normal controls, meanwhile, the level of Lp(a) did not markedly increase in children with a family history of cerebrovascular events.Conclusions (1) It is necessary for children with a family history of myocardial infarction to have a test and to follow up for Lp(a) at the appropriate time. (2) Continued studies are being conducted on the changes of Lp(a) in children with a family history of cerebrovascular events.