OBJECTIVE: To study the value of cardial troponin T (cTnT) and neuro peptide Y (NTY) in hyperthyroic heart disease. METHODS: The concentrations of serum cTnT and NTY were measured by ELISA method in 23 patients with hyperthyroidism, and were correlated with the myocardial systolic functions (cardic index, CI; ejective fration, EF) before and after the treatment. RESULTS: The concentrations of cTnT, NTY, FT 3, FT 4 and blood pressure (BP) at the beginning were 0.13 ± 0.04 ng/L, 192.8 ± 7.1 ng/L, 36.79 ± 4.94 ng/L, 52.96 ± 16.18 ng/L and 123.69 ± 10.06 mmHg, which after the treatment were 0.06 ± 0.03 ng/L, 140.2 ± 5.1 ng/L, 11.52 ± 4.74 ng/L, 26.81 ± 5.18 ng/L and 105.00 ± 8.66 mmHg while TSH was lower at the beginning ( 1.21 ± 0.45 U/L) than after the treatment (1.84 ± 0.29 U/L) in hyperthyroidism (t= 2.185 , 2.08, 13.3, 4.53 and 4.84, respectively). The myocardial systolic functions were damaged in hyperthyroidism. The interrelations between NTY and CI, EF were negative in hyperthyroidism (r= -0.333 and -0.203 , Y= 276.21 - 21.785 X; Y= 0.632 - 2.902 X, respectively). CONCLUSIONS: The concentrations of NTY and cTnT are higher in hyperthyroic heart disease. The higher the NTY and cTnT concentrations, the worse the myocardial systolic functions.