Expression of CD45RA+ and CD45RO+ in PBMCs of Infants with RSV LRTIs

ZHANG Yan-Min; LEI Chun-Lian; CHENG Ge-Sheng; YANG Yu-Cong

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Chinese Journal of Contemporary Pediatrics ›› 2001, Vol. 3 ›› Issue (3) : 260-261.

ORIGINAL ARTICLE

Expression of CD45RA+ and CD45RO+ in PBMCs of Infants with RSV LRTIs

ZHANG Yan-Min, LEI Chun-Lian, CHENG Ge-Sheng, YANG Yu-Cong

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Abstract

OBJECTIVE: To study the expression of CD4+ (helper T lymphocyte), CD45RA+ and CD45RO+ in PBMCs of infants with RSV LRTIs. METHODS: CD4+ and CD45RA+ were detected in 30 patients with RSV LRTIs and CD45RO+ in PBMCs was also assayed except for CD+4 and CD45RO+ in 11 of them with the flow cytometric analysis. Nine healthy children were used as the controls. RESULTS: In RSV infants, CD4+ cells ［(32.74±10.60)%］ decreased and CD45RA+ ［(80.65±10.35)%］ increased compared with the controls ［(40.76±6.82)% and (67.34±7.54)%, respectively］ (P<0.01). CD45RO+ cells also decreased, but not significantly. CONCLUSIONS: There is a disorder of immune function in PBMCs in infants with RSV.

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RSV / T help lymphocyte / CD45 / Child

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ZHANG Yan-Min, LEI Chun-Lian, CHENG Ge-Sheng, YANG Yu-Cong. Expression of CD45RA+ and CD45RO+ in PBMCs of Infants with RSV LRTIs[J]. Chinese Journal of Contemporary Pediatrics. 2001, 3(3): 260-261