OBJECTIVE: To study the therapeutic effect of high frequency oscillatory ventilation (HFOV) on respiratory failure in neonates. METHODS: One hundred and eighty six neonates with respiratory failure were treated by HFOV. PaO2, PaCO2 and SaO2 were measured before and after the treatment of HFOV. Of the 186 cases, 143 developed respiratory failure from serious asphxia complicated by the meconium aspiration. Besides PaO2, PaCO2 and SaO2, PaO2/FiO2, a/A PaO2 and oxygenation index were measured in the 143 cases. RESULTS: Eight hours after the treatment of HFOV, compared with the condifion before the treatment, PaO2 and SaO2 increased significantly [( 7.50 ± 1.38 ) kPa vs ( 4.37 ± 0.49 ) kPa and ( 91.22 ± 1.23 )% vs ( 34.70 ± 2.92 ) %, respectively](P< 0.01 ) and PaCO2 decreased significantly [( 4.41 ± 0.37 ) vs ( 9.43 ± 0.51 ) kPa](P< 0.01 ) in 186 cases; the oxygenation index decreased significantly [(16±6) vs (23±7)](P< 0.05 ) and the ratio of P aO 2/F iO 2 and a/A P aO 2 were elevated significantly [(10±5) vs (6±4) and ( 0.12 ± 0.06 ) vs ( 0.07 ± 0.05 ),respectively](P< 0.01 ) in 143 cases. Of the 186 cases, 145 were cured ( 77.96% ), 27 died ( 14.51% ) and 14 were discharged free of treatment. CONCLUSIONS: HFOV is effective on improving pulmonary air exchange in neonates with respiratory failure. It is necessary to use HFOV in infants with meconium aspiration earlier."/>
High Frequency Oscillatory Ventilation in the Treatment of Respiratory Failure in Neonates
Abstract OBJECTIVE: To study the therapeutic effect of high frequency oscillatory ventilation (HFOV) on respiratory failure in neonates. METHODS: One hundred and eighty six neonates with respiratory failure were treated by HFOV. PaO2, PaCO2 and SaO2 were measured before and after the treatment of HFOV. Of the 186 cases, 143 developed respiratory failure from serious asphxia complicated by the meconium aspiration. Besides PaO2, PaCO2 and SaO2, PaO2/FiO2, a/A PaO2 and oxygenation index were measured in the 143 cases. RESULTS: Eight hours after the treatment of HFOV, compared with the condifion before the treatment, PaO2 and SaO2 increased significantly [( 7.50 ± 1.38 ) kPa vs ( 4.37 ± 0.49 ) kPa and ( 91.22 ± 1.23 )% vs ( 34.70 ± 2.92 ) %, respectively](P< 0.01 ) and PaCO2 decreased significantly [( 4.41 ± 0.37 ) vs ( 9.43 ± 0.51 ) kPa](P< 0.01 ) in 186 cases; the oxygenation index decreased significantly [(16±6) vs (23±7)](P< 0.05 ) and the ratio of P aO 2/F iO 2 and a/A P aO 2 were elevated significantly [(10±5) vs (6±4) and ( 0.12 ± 0.06 ) vs ( 0.07 ± 0.05 ),respectively](P< 0.01 ) in 143 cases. Of the 186 cases, 145 were cured ( 77.96% ), 27 died ( 14.51% ) and 14 were discharged free of treatment. CONCLUSIONS: HFOV is effective on improving pulmonary air exchange in neonates with respiratory failure. It is necessary to use HFOV in infants with meconium aspiration earlier.
