Neonatal hypoxic2ischemic encephalopathy (HIE) is a severe complication of perinatal asphyxia. There are differences in the diagnostic criteria for HIE between China and overseas. The criteria of China do not include blood gas results of umbilical artery and incidence of multiple organs disorder (MOD) and can easily lead to misdiagnosis , while the oversea criteria are more scientific , perfect but over2strict which may result in missed diagnosis. At present , there are no highly specific and sensitive indexes for its diagnosis. So it is suggested that a diagnosis of HIE should be made according to history ,Apgar score , blood gas results , incidence of MOD ,brain images and clinic manifestations , etc.