The aim of this article is to improve the clinician's cognition to the cryptococcosis through a case of analysis of disseminated cryptococcosis. Cryptococcosis is a kind of deep mycosis caused by cryptococcus neoformans. Because the clinical manifestion of this disease has no specificity and it is easy to be misdiagnosed. The disease starts insidiously and often occurrs in patients who are in low resistance or have been treated with either broad spectrum antibiotics, hormone, antimetabolites, immuno-suppressive agents and anti-tumor drugs for a long time and have been on venous cannulation or indwelling urinary catheter for a long time. The clinical manifestions of the disorder include fever, swelling of liver, spleen and lymph nodes, lesions of liver function, skin, lung, skeleton and central nervous system. The final diagnosis depends on the finding of cryptococcus in lesion tissues or fluid by Chinese ink staining or biopsy. The differential diagnosis should be made with tubercular meningitis, sepsis and lymphoma. The disease should be treated with at least two to three antifungal medicines.