Abstract Objective Cough variant asthma (CVA) is correlated with interleukin-13 (IL-13) and characterized by inflammation of the air way. Among the products induced by IL-13, squamous cell carcinoma antigen (SccAg) is of the highest amount, which suggests that SccAg may play a role in the pathogenesis of CVA. This study aims to evaluate the values of IL-13, SccAg and immunoglobulin E (IgE) in CVA. Methods Serum IL-13, SccAg and IgE levels were measured using enzyme-linked immunosorbent assay (ELISA) in 51 children with CVA (CVA group), 26 with asthma (Asthma group) and 33 normal children (Normal control group). Results ① In the CVA group, serum levels of IL-13 ( 238.88± 40.07 ng/L) and SccAg ( 2.81± 0.38 ng/ml) on the acute phase were significantly higher than those on the remission phase ( 85.15± 17.98 ng/L and 2.29± 0.31 ng/ml, respectively; P< 0.01). No differences were found between the remission phase patients from the CVA group and the Normal control group. ② There were significant differences in the serum IgE level between the patients from the acute and remission phases in the CVA group ( 622.48± 295.01 KU/L vs 373.81± 157.92 KU/L; P< 0.01), and the serum levels of both the acute and remission phases were significantly higher than that of the Normal control group ( 102.99± 38.81 KU/L; both P< 0.01). ③ The serum IL-13, SccAg and IgE levels in the CVA group on the acute phase were not statistically different from those of the Asthma group. Conclusions The detection of serum IL-13, SccAg and IgE levels may be valuable in the diagnosis and treatment of CVA. IL-13 and SccAg may play a role in the genesis of CVA. The pathogenesis of CVA might be identical to asthma, and CVA seems to be a pioneer manifestation of typical asthma.
LUAN Bin,ZHANG Yan-Li,QIAO Jun-Ying. Levels of serum IL-13, squamous cell carcinoma antigen and IgE in children with cough variant asthma[J]. 中国当代儿科杂志, 2004, 6(5): 388-390.
LUAN Bin,ZHANG Yan-Li,QIAO Jun-Ying. Levels of serum IL-13, squamous cell carcinoma antigen and IgE in children with cough variant asthma[J]. CJCP, 2004, 6(5): 388-390.
