McCune-Albright syndrome: a difficult and complicated case study
LIANG Li-Yang, MENG Zhe, ZENG Qiao-Hui, LI Wen-Yi
Department of Pediatrics, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China. doctorlly@yahoo.com.cn
Abstract McCune-Albright syndrome is a rare G proteins α disorder. The disorder is characterized by polyostotic fibrous dysplasia, sexual precocity and hyperpigmented macules. It is caused due to mutations in the gene Gsα that incodes the α subunit of the trimeric guanosine triphate-binding protein. There is no specific treatment for this syndrome. Treatment is generally symptomatic. This paper reported three cases of McCune-Albright syndrome and reviewed the relevant literatures regarding to the pathogenesis, pathological features, diagnosis and treatment. All three cases presented with a characteristic triad: polyostotic fibrous dysplasia, sexual precocity and hyperpigmented macules and were thus definitely diagnosed with McCune-Albright syndrome.
Key words ：
McCune-Albright syndrome
Manifestation
Etiology
Diagnosis
Treatment
Child
Cite this article:
LIANG Li-Yang,MENG Zhe,ZENG Qiao-Hui et al. McCune-Albright syndrome: a difficult and complicated case study[J]. 中国当代儿科杂志, 2006, 8(4): 311-314.
LIANG Li-Yang,MENG Zhe,ZENG Qiao-Hui et al. McCune-Albright syndrome: a difficult and complicated case study[J]. CJCP, 2006, 8(4): 311-314.
URL:
http://www.zgddek.com/EN/ OR http://www.zgddek.com/EN/Y2006/V8/I4/311
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