The guideline provides evidence-based recommendations for parenteral and enteral nutrition to neonates in a critical state. It is developed by the interdisciplinary expert group in accordance with officially accepted standards based on various relevant literatures. The guideline is organized into the following sections: enteral nutrition (EN) support, parenteral nutrition (PN) support and a combination of PN & EN support. The EN or PN therapy provides appropriate energy and nutrients to babies that cannot be fed by oral route. For the premature and the very low birth weight infants with delayed gastric emptying and intestinal peristalsis, neurological immaturity and respiratory compromise, the PN therapy is the only choice. The formula to calculate the calorie supplement by PN is offered in the guideline when a combination of PN & EN support is administered.