Expression of CD21 in peripheral blood B lymphocytes of neonates
ZHANG Rong, WANG Qiong-Jin, XU Jin-Mei, JIANG Li, SHOU Wei-Zhang, YIN Yan.
Department of Pediatrics, Yangzhou First People's Hospital, Yangzhou, Jiangsu 225001, China.
Abstract OBJECTIVE: To study the cause of low immunologic function and insufficiency of immunoglubulin synthesis in neonates by detecting CD21 expression in B lymphocytes in different age group children.MethodsThis study consisted of three age group children: 2-26 days (n=18), 6 months-2 years (n=12) and 3-12 years (n=17). CD21 expression in B lymphocytes was detected with flow cytometry. Serum levels of immunoglobulins were measured by immunoturbidimetry. RESULTS: The percentage and the number of B lymphocytes expressing CD21 in the neonate group were significantly lower than in the other two age groups. The neonate group also showed lower mean fluorescence intension (MFI) of CD21. The percentage and the number of B lymphocytes expressing CD21 as well as the MFI of CD21 increased significantly with the age. The serum levels of IgA and IgM in the neonate group were noticeably lower than those in the other two age groups. The serum levels of IgA and IgM also increased significantly with the age. CONCLUSIONS: Low CD21 expression in B lymphocytes may be related to low function of humoral immunity in neonates.［Chin J Contemp Pediatr, 2007, 9 (6):546-548］
Key words ：
B lymphocyte
CD21
Immunoglobulin
T cell independent antigen
Neonate
Cite this article:
ZHANG Rong,WANG Qiong-Jin,XU Jin-Mei et al. Expression of CD21 in peripheral blood B lymphocytes of neonates[J]. 中国当代儿科杂志, 2007, 9(6): 546-548.
ZHANG Rong,WANG Qiong-Jin,XU Jin-Mei et al. Expression of CD21 in peripheral blood B lymphocytes of neonates[J]. CJCP, 2007, 9(6): 546-548.
URL:
http://www.zgddek.com/EN/ OR http://www.zgddek.com/EN/Y2007/V9/I6/546
[1]
XIAO Tian-Tian, JIN Mei, JU Rong, YANG Sheng, GAO Shu-Qiang, JIANG Yan, ZHANG Xiao-Long. Value of bedside lung ultrasound in the diagnosis of neonatal pneumonia
[2]
ZOU Rong, TANG Jun, BAO Shan, WU Tian, HUANG Jing-Lan, QU Yi, MU De-Zhi. Current status of the application of 1 H-magnetic resonance spectroscopy in neonates with hypoxic-ischemic encephalopathy
[3]
HUANG Xiao-Yun, LIU Hui-Long, LEI Min, LIAN Zhao-Hui, MAI Hui-Fen. Kaup index in 16 887 singleton neonates with a gestational age of 27-42 weeks in Shenzhen, China
[4]
YI Fang, WANG Ling, WANG Mei, YUAN Xue-Lian, WAN Hua-Jing, LI Jia-Yuan. Combined effect of gestational age and birth weight on metabolites related to inherited metabolic diseases in neonates
[5]
LING Qi-Ying, CHEN Hong, TANG Min, QU Yi, TANG Bin-Zhi. Efficiency of electrocardiogram monitor for positioning the catheter tip in peripherally inserted central catheter placement in neonates
[6]
FAN Shu-Juan, XIANG Jun-Xi, XIAO Mi, WANG Fang-Hui, LIN Xiao-Jie, ZHOU Xi-Hui, AI Ting, LIU Li. Influence of acute pancreatitis in pregnancy on pregnancy outcomes and neonates
[7]
HUANG Xiao-Yun, LIU Hui-Long, LEI Min, LIAN Zhao-Hui, MAI Hui-Fen. Intrauterine growth status of twin neonates with a gestational age of 27-40 weeks
[8]
SHI Yuan, CHEN Yan-Ru, CHEN Long. Application of real world study in neonatal medicine
[9]
BA Rui-Hua, MAO Jian. Correlation between magnetic resonance imaging score and clinical grading in neonatal hypoxic-ischemic encephalopathy
[10]
GAN Xin, LI Juan. Research advances in necrotizing enterocolitis in neonates
[11]
HUANG Xiao-Yun, LIU Hui-Long, LEI Min, LIAN Zhao-Hui, MAI Hui-Fen. A study of Ververck index in 16 865 singleton neonates with a gestational age of 27-42 weeks in Shenzhen, China
[12]
YUAN Wen-Hao, ZENG Ling-Kong, CAI Bao-Huan, LIU Xiao-Yan, WANG Shi, ZHAO Ling-Xia, HUANG Yan-Ping, WANG QIAO-Ling, LIU Han-Chu. Value of arterial blood lactic acid in the evaluation of disease severity and prognosis in neonatal shock
[13]
CHENG Ying, LIANG Hong, CAI Na-Li, GUO Li, HUANG Yu-Ge, SONG Yuan-Zong. Clinical features and MYO5B mutations of a family affected by microvillus inclusion disease
[14]
LIU Yi, ZHUO Lin, ZHU Bei, HE Ming-Yu, XU Yang, WANG Tong-Tong, HU Bin, XU Ji-Cheng. Association between depression during pregnancy and low birth weight in neonates:a Meta analysis
[15]
HUANG Xiao-Yun, LIU Hui-Long, LEI Min, MAI Hui-Fen, LIAN Chao-Hui, LI You-Cong. Intrauterine growth curves for body weight, body length, head circumference, chest circumference, and crown-rump length in 16 887 neonates with a gestational age of 27-42 weeks in Shenzhen, China
