Karyotypes and pelvic ultrasonography in children with Turner syndrome

LIANG Yan, CHENG Jing, CAi Yan-Na, WEI Xiao-Ping

Chinese Journal of Contemporary Pediatrics ›› 2008, Vol. 10 ›› Issue (2) : 158-160.

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PDF(1167 KB)
Chinese Journal of Contemporary Pediatrics ›› 2008, Vol. 10 ›› Issue (2) : 158-160.
CLINICAL RESEARCH

Karyotypes and pelvic ultrasonography in children with Turner syndrome

  •  LIANG Yan, CHENG Jing, CAi Yan-Na, WEI Xiao-Ping
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Abstract

OBJECTIVE: To study the relationship of karyotypes and gonadal development in children with Turner syndrome. METHODS: Fifty-one children with Turner syndrome were studied. Pelvic ultrasonography was performed on the children. Twenty healthy age-matched girls were used as control group. RESULTS: Eleven kinds of karyotypes were detected in 51 children with Turner syndrome. Children were classified into two groups based on karyotypes: Group 1 (45,XO; n= 24) and Group 2 (karyotypes other than 45, XO; n=27). 45,XO karyotype was the most common (47.1%), followed by 46,X,i (Xq)/45, XO (21.6%), 46,XX/45, XO (7.8%) and 47,XXX/45, XO (5.9%). Pelvic ultrasonography showed a primordial uterus in 41 cases, infantile uterus in 7 cases, congenital absence of uterus and ovary in 3 cases, simple anovarism in 42 cases and ovarian dysgenesis in 6 cases. Uterine size in both Groups 1 and 2 were significantly smaller than those of the control group (P<0.05). Group 1 showed smaller size of uterus than Group 2 (P<0.05). Ovaries were not detected in all Group 1 patients. CONCLUSIONS: The dysplasia and atrophy of ovaries and uterus exist in children with Turner syndrome. The patients with 45,XO karyotype had poorer gonadal development than those with other karyotypes.

Key words

Turner syndrome / Karyotypes / Pelvic ultrasonography / Child

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LIANG Yan, CHENG Jing, CAi Yan-Na, WEI Xiao-Ping. Karyotypes and pelvic ultrasonography in children with Turner syndrome[J]. Chinese Journal of Contemporary Pediatrics. 2008, 10(2): 158-160
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