［1］Rees MD, Kennett EC, Whitelock JM, Davies MJ. Oxidative damage to extracellular matrix and its role in human pathologies［J］. Free Radic Biol Med, 2008, 44(12):1973-2001.
［2］Outten CE, Falk RL, Culotta VC. Cellular factors required for protection from hyperoxia toxicity in Saccharomyces cerevisiae［J］. Biochem J, 2005, 388(Pt 1):93-101.
［3］Parinandi NL, Kleinberg MA, Usatyuk PV, Cummings RJ, Pennathur A, Cardounel AJ, et al. Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells［J］. Am J Physiol Lung Cell Mol Physiol, 2003, 284(1):L26-38.
［4］Zhang X, Shan P, Sasidhar M, Chupp GL, Flavell RA, Choi AM, et al. Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium［J］. Am J Respir Cell Mol Biol, 2003, 28(3):305-315.
［5］Buss IH, Darlow BA, Winterbourn CC. Elevated protein carbonyls and lipid peroxidation products correlating with myeloperoxidase in tracheal aspirates from premature infants［J］. Pediatr Res, 2000, 47(5):640-645.
［6］Kaarteenaho-Wiik R, Kinnula VL. Distribution of antioxidant enzymes in developing human lung, respiratory distress syndrome, and bronchopulmonary dysplasia［J］. J Histochem Cytochem, 2004, 52(9):1231-1240.
［7］Morton RL, Das KC, Guo XL, Iklé DN, White CW. Effect of oxygen on lung superoxide dismutase activities in premature baboons with bronchopulmonary dysplasia［J］. Am J Physiol, 1999, 276(1 Pt 1):L64-74.
［8］Sosenko IR, Chen Y, Price LT, Frank L. Failure of premature rabbits to increase lung antioxidant enzyme activities after hyperoxic exposure: antioxidant enzyme gene expression and pharmacologic intervention with endotoxin and dexamethasone［J］. Pediatr Res, 1995, 37(4 Pt 1):469-475.
［9］Mamo LB, Suliman HB, Giles BL, Auten RL, Piantadosi CA, Nozik-Grayck E. Discordant extracellular superoxide dismutase expression and activity in neonatal hyperoxic lung［J］. Am J Respir Crit Care Med, 2004, 170(3):313-318.
［10］Ho YS, Xiong Y, Ma W, Spector A, Ho DS. Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury［J］. J Biol Chem, 2004, 279(31):32804-32812.
［11］Heyob KM, Rogers LK, Welty SE. Glutathione reductase Targeted to type II cells does not protect mice from hyperoxic lung injury［J］. Am J Respir Cell Mol Biol, 2008, 39(6):683-688.
［12］Reddy NM, Kleeberger SR, Cho HY, Yamamoto M, Kensler TW, Biswal S, et al. Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants［J］. Am J Respir Cell Mol Biol, 2007, 37(1):3-8.
［13］Tipple TE, Welty SE, Rogers LK, Hansen TN, Choi YE, Kehrer JP, et al. Thioredoxin-related mechanisms in hyperoxic lung injury in mice［J］. Am J Respir Cell Mol Biol, 2007, 37(4):405-413.
［14］Walters DM, Cho HY, Kleeberger SR. Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2［J］. Antioxid Redox Signal, 2008, 10(2):321-332.
［15］Cho HY, Kleeberger SR. Genetic mechanisms of susceptibility to oxidative lung injury in mice［J］. Free Radic Biol Med, 2007, 42(4):433-445.
［16］Maróti Z, Katona M, Orvos H, Németh I, Farkas I, Túri S. Heme oxygenase-1 expression in premature and mature neonates during the first week of life［J］. Eur J Pediatr, 2007, 166 (10):1033-1038.
［17］Koo HC, Davis JM, Li Y, Hatzis D, Opsimos H, Pollack S, et al. Effects of transgene expression of superoxide dismutase and glutathione peroxidase on pulmonary epithelial cell growth in hyperoxia［J］. Am J Physiol Lung Cell Mol Physiol, 2005, 288(4):L718-726.
［18］O′Donovan DJ, Katkin JP, Tamura T, Smith CV, Welty SE. Attenuation of hyperoxia-induced growth inhibition in H441 cells by gene transfer of mitochondrially targeted glutathione reductase［J］. Am J Respir Cell Mol Biol, 2000, 22(6):732-738.
［19］Ogunlesi F, Cho C, McGrath-Morrow SA. The effect of glutamine on A549 cells exposed to moderate hyperoxia［J］. Biochim Biophys Acta, 2004, 1688(2):112-120.
［20］Ho YS. Transgenic and knockout models for studying the role of lung antioxidant enzymes in defense against hyperoxia［J］. Am J Respir Crit Care Med, 2002, 166(12 Pt 2):S51-56.
［21］Ahmed MN, Suliman HB, Folz RJ, Nozik-Grayck E, Golson ML, Mason SN, et al. Extracellular superoxide dismutase protects lung development in hyperoxiaexposed newborn mice［J］. Am J Respir Crit Care Med, 2003, 167(3):400405.
［22］Zhang X, Shan P, Jiang G, Zhang SS, Otterbein LE, Fu XY, et al. Endothelial STAT3 is essential for the protective effects of HO1 in oxidantinduced lung injury［J］. FASEB J, 2007, 21(2):21562158.
［23］Chang LY, Subramaniam M, Yoder BA, Day BJ, Ellison MC, Sunday ME, et al. A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia［J］. Am J Respir Crit Care Med, 2003, 167(1):5764.
［24］Nagata K, Iwasaki Y, Yamada T, Yuba T, Kono K, Hosogi S, et al. Overexpression of manganese superoxide dismutase by Nacetylcysteine in hyperoxic lung injury［J］. Respir Med, 2007, 101(4):800807.
［25］Thomas W, Speer CP. Nonventilatory strategies for prevention and treatment of bronchopulmonary dysplasiawhat is the evidence?［J］. Neonatology, 2008, 94(3):150159.
［26］Jobe AH. An unanticipated benefit of the treatment of preterm infants with CuZn superoxide dismutase［J］. Pediatrics, 2003, 111(3):680.