Roles of matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase and hs-CRP in Kawasaki disease

CHEN Rui; ZHANG Ai-Rong; ZHAO Xin-Xi; LI Zhan-Hua

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Chinese Journal of Contemporary Pediatrics ›› 2009, Vol. 11 ›› Issue (12) : 989-991.

CLINICAL RESEARCH

Roles of matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase and hs-CRP in Kawasaki disease

CHEN Rui, ZHANG Ai-Rong, ZHAO Xin-Xi, LI Zhan-Hua

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Abstract

OBJECTIVE: To examine the expression of matrix metalloproteinases (MMP)-2, -9, tissue inhibitor of matrix metalloproteinase (TIMP)-1 and hs-CRP, and their relationship with coronary artery in children with Kawasaki disease. METHODS: One hundred and fifty-one children with Kawasaki disease (111 cases with coronary artery damage and 40 cases without) and 60 healthy children were enrolled. The expression of MMP-2, MMP-9 and TIMP-1 was detected using ELISA, and the hs-CRP concentration was measured using the endpoint nephelometry. RESULTS: There were significant differences in the level of MMP-2, MMP-9 and hs-CRP between the patients with or without coronary artery damage and the healthy children (P<0.05). The levels of MMP-2, MMP-9 and hs-CRP were the highest in the cardiovascular damage group (P<0.05). There were positive correlations between MMP-2, MMP-9 and TIMP-1 in children with Kawasaki disease. CONCLUSIONS: MMP-2, MMP-9, TIMP-1 and hs-CRP may play important roles in the development of Kawasaki disease. The combined measurement of MMP-2, MMP-9 and hs-CRP may be useful in the evaluation of the severity in children with Kawasaki disease.［Chin J Contemp Pediatr, 2009, 11 (12):989-991］

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Kawasaki disease / MMP-2 / MMP-9 / TIMP-1 / hs-CRP / Child

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CHEN Rui, ZHANG Ai-Rong, ZHAO Xin-Xi, LI Zhan-Hua. Roles of matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase and hs-CRP in Kawasaki disease[J]. Chinese Journal of Contemporary Pediatrics. 2009, 11(12): 989-991

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