Insulin-like growth factor 1 levels and their association with growth and development in infants aged 1-24 months

WANG Xin-Li; GE Mei-Ru; WU Wen-Yan; ZHANG Juan

PDF(961 KB)

Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (06) : 459-461.

CLINICAL RESEARCH

Insulin-like growth factor 1 levels and their association with growth and development in infants aged 1-24 months

WANG Xin-Li, GE Mei-Ru, WU Wen-Yan, ZHANG Juan

Author information +

History +

Abstract

OBJECTIVE: To study serum insulin-like growth factor 1 (IGF-1) levels and their association with growth and development in infants aged 1-24 mouths. METHODS: A total of 525 healthy infants (125 preterm, 400 term) were enrolled. Serum IGF-1 levels were measured using ELISA 1.5, 4, 6, 8, 12, 18 and 24 months after birth. The body weight and body length were simultaneously measured. RESULTS: Serum IGF-1 levels were the lowest in preterm infants 1.5 months after birth (86±60 ng/mL). Thereafter, serum IGF-1 levels increased, and were significantly higher than those in term infants between 4 and 12 months after birth. Serum IGF-1 levels in term infants were the highest (116±52 ng/mL) 1.5 months after birth during their life of 12 months old. Thereafter, serum IGF-1 levels decreased and reached to a nadir (69±58 ng/mL) 8 months after birth. IGF-I levels were positively correlated with the weight and the height (SDS) in both preterm and term infants. CONCLUSIONS: Serum IGF-1 levels are closely associated with growth and development in infants.［Chin J Contemp Pediatr, 2010, 12 (6):459-461］

Key words

Insulin-like growth factor 1 / Growth and development / Infant

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

WANG Xin-Li, GE Mei-Ru, WU Wen-Yan, ZHANG Juan. Insulin-like growth factor 1 levels and their association with growth and development in infants aged 1-24 months[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(06): 459-461

References

［1］Laron Z. Insulin-like growth factor 1 (IGF-1): a growth hormone［J］. Mol Pathol, 2001, 54(5):311-316.
［2］Kadowaki K, Waguri M, Nakanishi I, Miyashita Y, Nakayama M, Suehara N, et al. Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta［J ］. J Clin Endocrinol Metab, 2006, 91(12):5090-5094.
［3］Lofqvist C, Andersson E, Gelander L, Rosberg S, Hulthen L, Blum WF, et al. Reference values for insulin-like growth factor-binding protein-3 (IGFBP-3) and the ratio of insulin-like growth factor-I to IGFBP-3 throughout childhood and adolescence［J］. J Clin Endocrinol Metab, 2005, 90(3):1420-1427.
［4］邓洁英, 史轶蘩, 张殿喜, 潘慧, 伍学焱, 朱惠娟, 等. 胰岛素样生长因子Ⅰ对儿童青春发育启动的作用［J］.中华内分泌代谢杂志, 2005, 21(4):337-340.
［5］中华人民共和国卫生部妇幼保健与社区卫生司,九市儿童体格发育调查研究协作组，首都儿科研究所. 2005年中国九市7岁以下儿童体格发育调查研究［M］. 北京：人民卫生出版社，2008:89.
［6］Colón E, Zaman F, Axelson M, Larsson O, Carlsson-Skwirut C, Svechnikov KV, et al. Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development［J］.Endocrinology, 2007, 148(1):128-139.
［7］Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) ［J］. Cell, 1993, 75(1):59-72.
［8］Camacho-Hübner C, Woods KA, Clark AJ, Savage MO. Insulin-like growth factor (IGF)-I gene deletion［ J ］. Rev Endocr Metab Disord, 2002, 3(4):357-361.
［9］Frystyk J. Free insulin-like growth factors-measurements and relationships to growth hormone secretion and glucose homeostasis［J］.Growth Hormone IGF Res, 2004, 14（5）:337-375.