Randomized trail of nasal synchronized intermittent mandatory ventilation compared with nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome

GAO Wei-Wei; TAN San-Zhi; CHEN Yun-Bin; ZHANG Yong; WANG Yue

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Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (07) : 524-526.

Randomized trail of nasal synchronized intermittent mandatory ventilation compared with nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome

GAO Wei-Wei, TAN San-Zhi, CHEN Yun-Bin, ZHANG Yong, WANG Yue

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Abstract

OBJECTIVE: To compare the efficacy of nasal synchronized intermittent mandatory ventilation (nSIMV) and nasal continuous positive airway pressure (nCPAP) in preterm infants with respiratory distress syndrome (RDS). METHODS: Fifty preterm infants with RDS who received pulmonary surfactant were randomized to nSIMV and nCPAP groups after extubation. Clinical signs, symptoms and blood gas results following nSIMV or nCPAP were compared in the two groups. RESULTS: Compared with the nCPAP group, the nSIMV group had a lower incidence of failure respiratory support (24% vs 60%; P<0.05), a lower incidence of hypercarbonia (12% vs 40%; P<0.05) and a lower incidence of hypoxia (24% vs 36%; P<0.05). CONCLUSIONS: nSIMV is more effective in respiratory support in preterm infants with RDS.［Chin J Contemp Pediatr, 2010, 12 (7):524-526］

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Respiratory distress syndrome / Nasal continuous positive airway pressure / Nasal synchronized internittent mandatory ventilation / Preterm infant

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GAO Wei-Wei, TAN San-Zhi, CHEN Yun-Bin, ZHANG Yong, WANG Yue. Randomized trail of nasal synchronized intermittent mandatory ventilation compared with nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(07): 524-526

References

［1］金汉珍，黄德珉，官希吉. 实用新生儿学［M］. 第3版. 北京：人民卫生出版社，2003：421-427.
［2］赵孟陶，孟素芹，陶英纯，王妮. 早产儿肺透明膜病的多器官损害及预后分析［J］.中国实用儿科杂志，1998，13（6）：351.
［3］冯泽康，余宁熙，曾振锚.中华新生儿学［M］.南昌：江西科学出版社，1998：279-284.
［4］Arthurs S. Lung injury caused by mechanical ventilation ［J］. Chest, 1999,116(4):9s-11s.
［5］Dreyfuss D, Saumonn G. From ventilatorinduced lungs injury to multiple organ dysfunction? ［J］. Intensive Care Med, 1998, 24(2`):102-104.
［6］Greenough A, Dimitriou G, Prendergast M,Milner AD. Synchronized mechanical ventilation for respiratory support in newborn infant ［J］. Cochrane Database Syst Rev, 2001, (1): CD000456.
［7］Herrera CM, Gerhardt T, Claure N, Everett R, Musante G, Thomas C,et al. Effect of volume-guaranteed synchronized intermittent mandatory ventilation in preterm infant recovering from respiratory failure ［J］. Pediatrics, 2002, 110(3):529-533.
［8］Contencin P, Narcy P. Size of endotracheal tube and neonatal acquired subglottic stenosis. Study Group for Neonatology and Pediatric Emergencies in the Parision Area ［J］. Arch Otolaryngol Head Neck Surg, 1993, 119(8):815-819.
［9］Maury E, Gugielminotti J, Alzieu M, Qureshi T, Guidet B, Offenstadt G. How to identify patients with no risk for postextubation stridor ? ［J］. Crit Care, 2004, 19(1):23-28.
［10］Moretti C, Gizzi C, Papott P, Lampariello S, Capoferri M, Calcagnini G, et al. Comparing the effects of nasal synchronized positive pressure ventilation (nIPPV) and nasal continuous positive airway pressure (nCPAP) after extubation in very low birth weight infants ［J］. Early Hum Dev, 1999, 56(2-3):167-177.