OBJECTIVE: To investigate the efficacy of hemoperfusion treatment in children with acute tetramine poisoning. METHODS: Thirty-two children aged from 1 to 8 years ( mean 4.6±2.4 years) with acute tetramine poisoning received hemoperfusion treatment. Serum tetramine concentrations were measured by gas chromatography before hemoperfusion, 1 and 2 hrs after hemoperfusion initiation and 12 and 24 hrs by the end of hemoperfusion. The median time for full recovery of consciousness and the time to seizure control were observed. RESULTS: Seventeen children received hemoperfusion treatment for one time, 12 for twice, 2 for 4 times and 1 for 3 times. Twenty- seven (84%) cases recovered, 2 (7%) cases improved and 3 (9%) cases died of multi-organ failure. The serum tetramine concentrations 1 and 2 hrs after hrmoperfusion initiation were significantly lower than those before hemoperfusion (P<0.01). The serum tetramine concentrations 12 and 24 hrs by the end of hemoperfusion were also significantly lower than those before hemoperfusion (P<0.01). The median time for full recovery of consciousness and the time to seizure control were 5.4±4.2 and 10.1±7.3 hrs, respectively. CONCLUSIONS: Hemoperfusion treatment is effective for acute tetramine poisoning in children. ［Chin J Contemp Pediatr, 2010, 12 (7):536-538］