Prophylactic efficacy of levetiracetam, valproate or phenobarbital on febrile convulsions in rats

CHENG Min; HUANG Zhi; LI Si-Xiu

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Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (07) : 573-575.

EXPERIMENTAL RESEARCH

Prophylactic efficacy of levetiracetam, valproate or phenobarbital on febrile convulsions in rats

CHENG Min, HUANG Zhi, LI Si-Xiu

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Abstract

OBJECTIVE: To study and compare the prophylatic efficacy of levetiracetam, valproate and phenobarbital on febrile convulsions in rats. METHODS: Sixty Wistar rats were randomly administered with levetiracetam (200 mg/kg), valproate (250 mg/kg), phenobarbital (30 mg/kg) or normal saline (8 ml/kg) for 5 days. Five days later, febrile convulsions were induced by hyperthermal bath (45℃). The latency, duration and the severity of seizures were observed. RESULTS: In all the three drug-treated groups, the latency was significantly prolonged, and the duration and the severity of seizures were notably reduced compared with the saline group（P< 0.05 or 0.01）. The phenobarbital group had the shortest duration of seizures and the least severe seizures among the three drug-treated groups. There were no significant differences between the levetiracetam and valproate groups. CONCLUSIONS: Continuous administration of levetiracetam, valproate or phenobarbital is effective in preventing recurrent febrile convulsions in rats. Phenobarbital appears to be more effective than levetiracetam and valproate. There were no significant differences in the prophylactic efficacy between levetiracetam and valproate.［Chin J Contemp Pediatr, 2010, 12 (7):573-575］

Key words

Levetiracetam / Febrile convulsion / Prophylatic efficacy / Rats

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CHENG Min, HUANG Zhi, LI Si-Xiu. Prophylactic efficacy of levetiracetam, valproate or phenobarbital on febrile convulsions in rats[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(07): 573-575

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