Risk factors for nosocomial bloodstream infections in a neonatal intensive care unit

TIAN Luan-Ying; Aaron HAMVAS

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Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (08) : 622-624.

CLINICAL RESEARCH

Risk factors for nosocomial bloodstream infections in a neonatal intensive care unit

TIAN Luan-Ying, Aaron HAMVAS

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Abstract

OBJECTIVE: To assess the risk factors for nosocomial blood-stream infection (BSI) in a neonatal intensive care unit (NICU). METHODS: Clinical data from the neonates admitted to the NICU in the St. Louis Children’s Hospital in Washington University School of Medicine between January 2005 and December 2006 were retrospectively studied. RESULTS: A total of 1 290 neonates were included. Overall, 175 nosocomial BSIs occurred. Catheter-related BSIs accounted for 62.3% (109 cases). The incidence of nosocomial BSI was 4.22 per 1 000 patient-days. Logistic regression analysis revealed that low gestational age, low Apgar scores at 5 minutes, use of central venous catheter (CVC), and longer CVC use were risk factors for the development of nosocomial BSI. In the subgroup of neonates with CVC, mechanical ventilation was an additional independent risk factor for BSI. CONCLUSIONS: Catheter-related BSI is the major source of nosocomial BSI in the NICU. Prematurity, low Apgar scores at birth and prolonged CVC use are risk factors for the development of BSI.［Chin J Contemp Pediatr, 2010, 12 (8):622-624］

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Intensive care unit / Nosocomial bloodstream infection / Risk factor / Neonate

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TIAN Luan-Ying, Aaron HAMVAS. Risk factors for nosocomial bloodstream infections in a neonatal intensive care unit[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(08): 622-624

References

［1］Garner JS, Jarvis WR, Emori TG, Hughes JM. CDC definitions for nosocomial infections［J］. Am J Infect Control, 1988, 16（3）:128-140.
［2］Perlman SE, Saiman L, Larson EL. Risk factors for late-onset health care-associated bloodstream infections in patients in neonatal intensive care units［J］. Am J Infect Control, 2007, 35(3):177-182.
［3］Couto RC, Pedrosa TM, Tofani Cde P, Pedroso Enio RP. Risk factors for nosocomial infection in a neonatal intensive care unit［J］. Infect Control Hosp Epidemiol, 2006, 27(6): 571-575.
［4］National Nosocomial Infections Surveillance System. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004［J］. Am J Infect Control, 2004, 32(8): 470-485.
［5］Aly H, Herson V, Duncan A, Herr J, Bender J, Patel K, et al. Is bloodstream infection preventable among premature infants? A tale of two cities［J］. Pediatrics, 2005, 115(6):1513-1518.
［6］Golombek SG, Roham AJ, Parvez B, Salice AL, LaGamma EF. “Proactive” management of percutaneously inserted central catheters results in decreased incidence of infection in the ELBW population［J］. J Perinatol, 2002, 22(3):209-213.
［7］Timsit JF. Diagnosis and prevention of catheter-related infections［J］. Curr Opin Crit Care, 2007, 13(5):563-571.