Concentrations of granulocyte colony-stimulating factor in children with moyamoya disease

MA Ming-Sheng; ZOU Li-Ping; DING Ying-Xue; JIN Hong

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Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (2) : 117-119.

CLINICAL RESEARCH

Concentrations of granulocyte colony-stimulating factor in children with moyamoya disease

MA Ming-Sheng, ZOU Li-Ping, DING Ying-Xue, JIN Hong

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Abstract

OBJECTIVE: To explore the roles of granulocyte colony-stimulating factor in the pathogenesis of moyamoya disease. METHODS: Serum G-CSF concentrations were measured using enzyme linked immunosorbent assay (ELISA) in 20 children with moyamoya disease and 20 healthy children. RESULTS: Serum G-CSF concentration (35.7±10.3 pg/mL) in children with moyamoya disease was significantly higher than that in healthy controls (23.5±3.8 pg/mL) (P<0.01). CONCLUSIONS: The elevated serum G-CSF concentration in children with moyamoya disease suggests that G-CSF may play an important role in the pathogenesis of moyamoya disease.［Chin J Contemp Pediatr, 2010, 12 (2):117-119］

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Moyamoya disease / Granulocyte colony-stimulating factor / Child

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MA Ming-Sheng, ZOU Li-Ping, DING Ying-Xue, JIN Hong. Concentrations of granulocyte colony-stimulating factor in children with moyamoya disease[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(2): 117-119

References

［1］张正善，段炼，杨伟中，关良.烟雾病的病因研究［J］.中国卒中杂志, 2008, 3(7):488-492.
［2］金洪, 邹丽萍,段炼, 周春菊, 齐翔, 方方,等. 肝细胞生长因子在烟雾病发病机制中的作用［J］.中风与神经疾病杂志, 2007, 24(2):150-153.
［3］Demetri GD, Griffin JD. Granulocyte colony-stimulating factor and its receptor［J］. Blood, 1991, 78(11):2791-2808.
［4］Xiao BG, Lu CZ, Link H.Cell biology and clinical promise of G-CSF: immunomodulation and neuroprotection［J］. Cell Mol Med, 2007, 11(6):1272-1290.
［5］高山.烟雾病诊断标准［J］.中国卒中杂志, 2008, 3(7):500-501.
［6］Kawakami M, Tsutsumi H, Kumakawa T, Abe H, Hirai M, Kurosawa S, et al. Levels of serum granulocyte colony-stimulating factor in patients with infections［J］. Blood, 1990, 76(10):1962-1964.
［7］Watari K, Asano S, Shirafuji N, Kodo H, Ozawa K, Takaku F, et al. Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay［J］. Blood, 1989, 73(1):117-122.
［8］Schneider A, Kruger C, Steigleder T, Weber D, Pitzer C, Laage R, et al. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis［J］. J Clin Invest, 2005, 115(8):2083-2098.
［9］Kleinschnitz C, Schroeter M, Jander S, Stoll G. Induction of granulocyte colony-stimulating factor mRNA by focal cerebral ischemia and cortical spreading depression［J］. Brain Res Mol Brain Res, 2004, 131(1-2):73-78.
［10］陈小江,许志恩,陈倍楚. 急性脑梗死后内源性G-CSF和CD34+细胞动员关系的研究［J］. 中国老年学杂志, 2008, 5(28):966-969.
［11］Ohki Y, Heissig B, Sato Y, Akiyama H, Zhu Z, Hicklin DJ, et al. Granulocyte colony-stimulating factor promotes neovascularization by releasing vascular endothelial growth factor from neutrophils［J］. FASEB J, 2005, 19(14):2005-2007.
［12］李骁雄.中枢神经系统血管畸形性疾病中VEGF的表达［J］. 国外医学神经病学神经外科学分册, 2001, 28(6):451-453.
［13］Sakamoto S, Kiura Y, Yamasaki F, Shibukawa M, Ohba S, Shrestha P, et al. Expression of vascular endothelial growth factor in dura mater of patients with moyamoya disease［J］. Neurosurg Rev, 2008, 31(1):77-81.