Investigation of nosocomial infection in the neonatal intensive care unit

CAI Xiao-Di; CAO Yun; CHEN Chao; YANG Yi; WANG Chuan-Qing; ZHANG Lan; DING Hong

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Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (2) : 81-84.

CLINICAL RESEARCH

Investigation of nosocomial infection in the neonatal intensive care unit

CAI Xiao-Di, CAO Yun, CHEN Chao, YANG Yi, WANG Chuan-Qing, ZHANG Lan, DING Hong

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Abstract

OBJECTIVE: A perspective study was conducted to describe the epidemiologic profile of nosocomial infection in the neonatal intensive care unit (NICU). METHODS: The newborn infants who were admitted in the NICU for more than 48 hrs were enrolled from February 2006 to January 2007. The clinical data were collected. The rate of nosocomial infection was calculated according to the CDC surveillance system. The risk factors of nosocomial infection were investigated by multivariate regression analysis. RESULTS: A total of 1 159 neonates were recruited. A total of 169 nosocomial infections occurred, with a cumulative rate for nosocomial infection of 14.58%. The incidence of nosocomial infection was 19.52 per 1 000 patient-days. Ninety-two cases of pneumonia, including 38 cases of ventilator-associated pneumonia (VAP), were reported, with a nosocomial infection rate of 7.94%, which was the most common nosocomial infection in the NICU. Among these infants the rate of VAP was 48.8 per 1 000 ventilator days. The major microorganisms isolated from the infected patients were Acinetobacter baumannii, Klebsiella pneumoniae, Coagulase negative staphylococcus, and aeruginosus Bacillus. Birth weight (OR 2.130, 95%CI 1.466-3.094), mechanical ventilation (OR 7.038, 95%CI 3.901-12.698), chest tube drainage (OR 7.004, 95%CI 1.841-26.653) and ibuprofen therapy (OR 2.907, 95% CI 1.303-6.487) were the risk factors for the development of nosocomial infection. CONCLUSIONS: Pulmonary infection is the most common nosocomial infection in the NICU, and the Gram-negative bacillus is the main pathogen. Low birth weight, mechanical ventilation, chest tube drainage and ibuprofen therapy are independent risk factors for nosocomial infection in the NICU.［Chin J Contemp Pediatr, 2010, 12 (2):81-84］

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Intensive Care Unit / Nosocomial infection / Risk factor / Neonate

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CAI Xiao-Di, CAO Yun, CHEN Chao, YANG Yi, WANG Chuan-Qing, ZHANG Lan, DING Hong. Investigation of nosocomial infection in the neonatal intensive care unit[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(2): 81-84

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