Effects of probiotics on intestinal bacterial colonization in premature infants

REN Ya-Fang, WANG Li-Li

Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (3) : 192-194.

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Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (3) : 192-194.
CLINICAL RESEARCH

Effects of probiotics on intestinal bacterial colonization in premature infants

  • REN Ya-Fang, WANG Li-Li
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Abstract

OBJECTIVE: To study the possible roles of probiotics in decreasing intestinal bacterial colonization rate and the incidence of enterogenic infections in premature infants. METHODS: Seventy premature infants were randomly assigned to two groups: probiotics and conventional treatment groups (control) (n=35 each). The probiotics treatment group was administered with oral Clostridium butyricum powder (250 mg, twice daily up to discharge) 24 hrs after birth except conventional treatment. Rectal swab cultures were done at admission, 5 and 12 days after admission, and before discharge. Clinical and laboratory findings were compared between the two groups. RESULTS: The intestinal bacterial colonization rate in the probiotics treatment group was lower than that in the control group 12 days after admission (60% vs 83%; P<0.05) and before discharge (51% vs 80%; P<0.05). Klebsiella pneumoniae, Escherichia coli and Enterococcus faecium were common colonization bacteria in the two groups. Diarrhea occurred in 7 cases (20%) in the probiotics treatment group compared with 16 cases (46%) in the control group (P<0.05). Two infants (6%) developed sepsis in the probiotics treatment group compared with 9 cases (26%) in the control group (P<0.05). CONCLUSIONS: Probiotics can decrease intestinal bacterial colonization rate and the incidence of diarrhea and sepsis in premature infants.[Chin J Contemp Pediatr, 2010, 12 (3):192-194]

Key words

Probiotics / Bacterial colonization / Premature infants

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REN Ya-Fang, WANG Li-Li. Effects of probiotics on intestinal bacterial colonization in premature infants[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(3): 192-194

References

[1]胡亚美,江载芳.诸福棠实用儿科学[M].第7版.北京:人民卫生出版社, 2002:1289-1294.
[2]余加林,吴仕孝.新生儿败血症诊疗方案[J].中华儿科杂志,2003,41(12):897-899.
[3]Rautava S. Potential use of probiotics in the neonate[J].Semin Fetal Neonatal Med,2007,12(1):45-53.
[4]Wenzl HH, Schimpl G, Feierl G, Steinwender G. Time course of spontaneous bacterial translocation from gastrointestinal trace and its relationship to intestinal microflora in conventionally reared infant rats[J].Dig Dis Sci, 2001, 46(5):1120-1126.
[5]Lee SJ, Cho SJ, Park EA. Effects of probiotics on enteric flora and feeding to tolerance in preterm infants[J].Neonatology, 2007, 91(3):174-179.
[6]Lin HC, Su BH, Chen AC, Lin TW, Tsai CH, Yeh TF, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants[J].Pediatrics, 2005, 115(1):1-4.
[7]Lin HC, Hsu CH, Chen HL, Chung MY, Hsu JF, Lien RI, et al.Oral probiotic prevent necrotizing enterocolitis in very low birth weight preterm infants:a multicenter randomized controlled trial[J].Pediatrics, 2008, 122(4):693-700.
[8]徐焱,张乐嘉,戈海延,王丹华.新生儿重症监护病房的院内感染638例分析[J].中华儿科杂志,2007,45(6),437-441.
[9]李联侨,吴斌,高璇璇,王素香,郑忠实,许嘉玲. 微生态制剂防治新生儿坏死性小肠结肠炎病例对照研究[J].中国当代儿科杂志,2006,8(6):464-466.
[10]徐焱,王丹华,徐英春.新生儿重症监护病房部分定植细菌定植特点及变化规律[J].临床儿科杂志,2008,26(3):209-212.

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