Abstract OBJECTIVE: To study the distribution and antibiotic resistance of gram-negative pathogens isolated from children with bronchopneumonia. METHODS: The distribution and the results of susceptibility tests of 272 strains of gram-negative Bacillis isolated from children with bronchopneumonia during 2009 were analyzed. RESULTS: Among the isolates, the common pathogens were Klebsiella pneumoniae and Escherichia coli. The extended-spectrum β-lactamase (ESBLs) production rate was 52.9%. Compared with the non-ESBLs producing strains, ESBLs-producing strains had a significantly higher drug resistance rate to many antibiotics except amikacin and meropenem (P<0.05). The lowest resistance to ESBLs producing gram negative strains was found for meropenem (0.7%), followed by imipenem, amikacin and cefoperazone/sulbactam. CONCLUSIONS: More attentions should be paid to the high rate of drug-resistance of ESBLs producing strains in children. Antimicrobial therapy should be based on the results of drug resistance surveillance.
WEI Hong-Yan,TAN Bo-Yu,YANG Li-Jun et al. Antibiotic resistance of gram-negative Bacillis isolated from children with bronchopneumonia[J]. 中国当代儿科杂志, 2011, 13(1): 20-22.
WEI Hong-Yan,TAN Bo-Yu,YANG Li-Jun et al. Antibiotic resistance of gram-negative Bacillis isolated from children with bronchopneumonia[J]. CJCP, 2011, 13(1): 20-22.
［5］Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: nineteenth information supplement M100-S20.CLSI ［S］. Wayne, PA, USA, 2009: 120-121.
［10］Cantón R, Morosini MI, de la Maza OM, de la Pedrosa EG. IRT and CMT beta-lactamases and inhibitor resistance［J］. Clin Microbiol Infect, 2008, 14 (Suppl 1): 53-62.
