OBJECTIVE: To study the distribution and antibiotic resistance of gram-negative pathogens isolated from children with bronchopneumonia. METHODS: The distribution and the results of susceptibility tests of 272 strains of gram-negative Bacillis isolated from children with bronchopneumonia during 2009 were analyzed. RESULTS: Among the isolates, the common pathogens were Klebsiella pneumoniae and Escherichia coli. The extended-spectrum β-lactamase (ESBLs) production rate was 52.9%. Compared with the non-ESBLs producing strains, ESBLs-producing strains had a significantly higher drug resistance rate to many antibiotics except amikacin and meropenem (P<0.05). The lowest resistance to ESBLs producing gram negative strains was found for meropenem (0.7%), followed by imipenem, amikacin and cefoperazone/sulbactam. CONCLUSIONS: More attentions should be paid to the high rate of drug-resistance of ESBLs producing strains in children. Antimicrobial therapy should be based on the results of drug resistance surveillance.
Key words
Gram-negitive bacilli /
Bronchopneumonia /
Drug resistance /
Child
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References
［1］华春珍，俞惠民，陈志敏，李建平，尚世强. 小儿下呼吸道感染的细菌病原学分析［J］. 中国当代儿科杂志，2006, 8(5): 365-368.
［2］董方，徐樨巍，宋文琪，吕萍，冯东霞，刘锡青，等. 2003-2008年儿科临床分离菌的分布变迁及耐药性监测［J］. 中国感染与化疗杂志，2009，9(6): 440-445.
［3］沈晓明，王卫平.儿科学［M］. 第七版.北京：人民卫生出版社，2008：273278.
［4］中华人民共和国卫生部医政司编.全国临床检验操作规程［M］. 第3版. 南京：东南大学出版社，2006：331-332.
［5］Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: nineteenth information supplement M100-S20.CLSI ［S］. Wayne, PA, USA, 2009: 120-121.
［6］郭军，崔振泽，黄燕，于爱民. 小儿急性呼吸道感染细菌分布及耐药状况［J］. 中国当代儿科杂志，2008，10 (5): 579-582.
［7］卓超，苏丹虹，朱德妹，胡付品，汪复，阮斐怡，等. 2007年CHINET大肠埃希菌和克雷伯菌属耐药性监测［J］. 中国感染与化疗杂志，2009, 9(3): 185-191.
［8］杨启文，徐英春，谢秀丽，王辉, 胡云建，倪语星，等. 全国 10 所医院院内与社区感染常见病原菌耐药性分析［J］. 中华医院感染学杂志，2009，19(9): 1133-1138.
［9］陶兴和，朱以军. 下呼吸道感染中非发酵菌的分布及耐药分析［J］. 中华医院感染学杂志，2010，20(2): 275-277.
［10］Cantón R, Morosini MI, de la Maza OM, de la Pedrosa EG. IRT and CMT beta-lactamases and inhibitor resistance［J］. Clin Microbiol Infect, 2008, 14 (Suppl 1): 53-62.
［11］仲兆金. 碳青霉烯类抗生素在儿科的临床应用［J］. 国外医药抗生素分册，2009, 30(2): 76-81.
［12］郭玲娇，李招云，张颖，陈贤君. 鲍氏不动杆菌感染及耐药性分析［J］. 中华医院感染学杂志，2007, 17(2): 216-217.
［13］丁玎，吕火祥. 非发酵菌对亚胺培南的耐药性分析［J］.中华医院感染学杂志，2004, 14(8): 926-928.
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