［1］Volpe JJ. Neonatal Seizures［M］ // Volpe JJ. Neurology of the newborn. 5th ed.  Philadelphia: Saunders, 2008: 203-237. ［2］Ramos-Lizana J, Aguilera-Lopez P, Aguirre-Rodriguez J, Cassinello-García E. Early prediction of refractory epilepsy in childhood［J］. Seizure, 2009, 18（6）：412-416. ［3］Bassan H, Ental Y, Shany E, Berger I, Froom P, Levi L, et al. Neonatal seizures: dilemmas in workup and management［J］. Pediatr Neurol, 2008, 38（6）: 415-421. ［4］Mastrangelo M, Van Lierde A, Bray M, Pastorino G, Marini A, Mosca F. Epileptic seizures, epilepsy and epileptic syndromes in newborns: a nosological approach to 94 new cases by the 2001 proposed diagnostic scheme for people with epileptic seizures and with epilepsy［J］. Seizure, 2005, 14（5）: 304-311. ［5］Garcias Da Silva LF, Nunes ML, Da Costa JC. Risk factors for developing epilepsy after neonatal seizures［J］. Pediatr Neurol, 2004, 30（4）: 271-277. ［6］Sanchez RM, Jensen FE. Maturational aspects of epilepsy mechanisms and consequences for the immature brain［J］. Epilepsia, 2001, 42（5）:577-585.  ［7］Thibeault-Eybalin MP, Lortie A, Carmant L. Neonatal seizures: do they damage the brain?［J］. Pediatr Neurol, 2009, 40（3）: 175-180. ［8］Friedman LK, Avallone JM, Magrys B. Maturational effects of single and multiple early-life seizures on AMPA receptors in prepubescent hippocampus［J］. Dev Neurosci, 2007, 29（6）: 427-437. ［9］Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC. A KCNQ channel opener for experimental neonatal seizures and status epilepticus［J］. Ann Neurol, 2009, 65（3）: 326-336. ［10］Scharfman HE, McCloskey DP. Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy［J］. Epilepsy Res, 2009, 85（2）: 150-161. ［11］Yager JY, Armstrong EA, Miyashita H, Wirrell EC. Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release［J］. Dev Neurosci, 2002, 24（5）: 367-381. ［12］Wasterlain CG, Niquet J, Thompson KW. Baldwin R, Liu H, Sankar R, et al. Seizure-induced neuronal death in the immature brain［J］. Prog Brain Res, 2002, 135(11): 335-353. ［13］De Rogalski LI, Minokoshi M, Silveira DC, Cha BH, Holmes GL. Recurrent neonatal seizures: relationship of pathology to the electroencephalogram and cognition［J］. Brain Res Dev Brain Res, 2001, 129（1）: 27-38. ［14］McCabe BK, Silveira DC, Cilio MR, Cha BH, Liu X, Sogawa Y, et al. Reduced neurogenesis after neonatal seizures［J］. J Neurosci, 2001, 21(6): 2094-2103. ［15］Campistol J. Inborn errors of metabolism with neurological manifestations in the neonatal period［J］. Medicina (B Aires), 2007, 67（6）: 561-568. ［16］Pisani F, Orsini M, Braibanti S, Copioli C, Sisti L, Turco EC. Development of epilepsy in newborns with moderate hypoxicischemic encephalopathy and neonatal seizures［J］. Brain Dev, 2009, 31（1）: 64-68. ［17］Montassir H, Maegaki Y, Ohno K, Ogura K. Long term prognosis of symptomatic occipital lobe epilepsy secondary to neonatal hypoglycemia［J］.Epilepsy Res, 2010, 88(2-3), 93-99. ［18］Yis U, Kurul SH, Dirik E. Nonketotic hyperglycinemia and acquired hydrocephalus［J］. Pediatr Neurol, 2009,40（2）: 138-140. ［19］Khayat M, Korman SH, Frankel P, Weintraub Z, Hershckowitz S, Sheffer VF, et al. PNPO deficiency: an under diagnosed inborn error of pyridoxine metabolism［J］. Mol Genet Metab, 2008, 94（4）: 431-434. ［20］Pearl PL, Hartka TR, Taylor J. Diagnosis and treatment of neurotransmitter disorders［J］. Curr Treat Options Neurol, 2006, 8（6）: 441-450. ［21］Hart CE, Race V, Achouri Y, Wiame E, Sharrard M, Olpin SE, et al. Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway［J］. Am J Hum Genet, 2007, 80（5）: 931-937. ［22］Mouchegh K, Zikanova M, Hoffmann GF, Kretzschmar B, Kuhn T, Mildenberger E, et al. Lethal fetal and early neonatal presentation of adenylosuccinate lyase deficiency: observation of 6 patients in 4 families［J］. J Pediatr, 2007, 150（1）: 57-61. ［23］Per H, Gumus H, Ichida K, Caglayan O, Kumandas S. Molybdenum cofactor deficiency: clinical features in a Turkish patient［J］. Brain Dev, 2007, 29（6）: 365-368. ［24］Kaczala GW, Messer MA, Poskitt KJ, Prendiville JS, Gardiner J, Senger C. Therapy resistant neonatal seizures, linear vesicular rash, and unusually early neuroradiological changes: incontinentia pigmenti: a case report, literature review and insight into pathogenesis［J］. Eur J Pediatr, 2008,167（9）: 979-983. ［25］Jocic-Jakubi B, Lagae L. Malignant migrating partial seizures in Aicardi syndrome［J］. Dev Med Child Neurol, 2008, 50（10）: 790-792. ［26］Carpinato C, Palano GM, Sottile E, Di Bella D, Distefano G. A case of isolated pachygyria with unusual clinical onset in the neonatal period［J］. Pediatr Med Chir, 2008, 30（4）: 204-207. ［27］Loddenkemper T, Alexopoulos AV, Kotagal P, Moosa A, Lachhwani DK, Gupta A, et al. Epilepsy surgery in epidermal nevus syndrome variant with hemimegalencephaly and intractable seizures［J］. J Neurol, 2008, 255（11）: 1829-1831. ［28］Hon SF, Wong GK, Zhu XL, Ng HK, Sin NC, Poon WS. et al. Surgical treatment of a neonate with refractory seizures secondary to congenital giant cell astrocytoma: case report and literature review［J］. Hong Kong Med J, 2006, 12（3）: 222-224. ［29］Romanelli P, Muacevic A, Striano S. Radiosurgery for hypothalamic hamartomas［J］. Neurosurg Focus, 2009, 24（5）: E9. ［30］Hyllienmark L, Amark P. Continuous EEG monitoring in a paediatric intensive care unit［J］. Eur J Paediatr Neurol, 2007, 11（2）: 70-75. ［31］Schmitt B, Wohlrab G, Sander T, Steinlein OK, Hajnal BL. Neonatal seizures with tonic clonic sequences and poor developmental outcome［J］. Epilepsy Resm, 2005, 65（3）: 161-168. ［32］Caravale B, Allemand F, Libenson MH. Factors predictive of seizures and neurologic outcome in perinatal depression［J］. Pediatr Neurol, 2003, 29（1）: 18-25. ［33］Boylan GB, Pressler RM, Rennie JM, Morton M, Leow PL, Hughes R, et al. Outcome of electroclinical, electrographic, and clinical seizures in the newborn infant［J］. Dev Med Child Neurol, 1999, 41（12）: 819-825. ［34］Shah DK, Mackay MT, Lavery S, Watson S, Harvey AS, Zempel J, et al. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants［J］. Pediatrics, 2008, 121（6）: 1146-1154. ［35］Rennie JM, Chorley G, Boylan GB, Pressler R, Nguyen Y, Hooper R, et al. Non-expert use of the cerebral function monitor for neonatal seizure detection［J］. Arch Dis Child Fetal Neonatal Ed, 2004, 89（1）: F37-40. ［36］Toet MC, van der Meij W, de Vries LS, Uiterwaal CS, van Huffelen KC. Comparison between simultaneously recorded amplitude integrated electroencephalogram (cerebral function monitor) and standard electroencephalogram in neonates［J］. Pediatrics, 2002, 109（5）: 772-779. ［37］Toet  MC, Groenendaal F, Osredkar D, van Huffelen AC, de Vries LS. Postneonatal epilepsy following amplitude-integrated EEG-detected neonatal seizures［J］. Pediatr Neurol, 2005, 32（4）: 241-247. ［38］Lawrence R, Mathur A, Nguyen TTS, Zempel J, Inder T. A pilot study of continuous limited-channel aEEG in term infants with encephalopathy［J］. J Pediatr, 2009, 154（6）: 835-841. ［39］Toet MC, Lemmers  PM. Brain monitoring in neonates［J］. Early Hum Dev, 2009, 85（2）: 77-84. ［40］Shellhaas RA, Clancy RR. Characterization of neonatal seizures by conventional EEG and singlechannel EEG［J］. Clin Neurophysiol, 2007, 118（10）: 2156-2161. ［41］Shellhaas RA, Soaita AI, Clancy RR. Sensitivity of amplitude-integrated electroencephalography for neonatal seizure detection［J］. Pediatrics, 2007, 120（4）: 770-777. ［42］Boylan GB, Rennie JM, Chorley G, Pressler RM, Fox GF, Farrer K, et al. Second-line anticonvulsant treatment of neonatal seizures: a videoEEG monitoring study［J］. Neurology, 2004, 62（3）: 486-488. ［43］Painter MJ, Scher MS, Stein AD, Armatti S, Wang Z, Gardiner JC, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures［J］. N Engl J Med, 1999, 341（7）: 485-489. ［44］Bartha AI, Shen J, Katz KH, Mischel RE, Yap KR, Ivacko JA, et al. Neonatal seizures: multicenter variability in current treatment practices［J］. Pediatr Neurol, 2007, 37（2）: 85-90. ［45］Yamamoto H, Aihara M, Niijima S, Yamanouchi H. Treatments with midazolam and lidocaine for status epilepticus in neonates［J］. Brain Dev, 2007, 29（9）: 559564. ［46］Shany E, Benzaqen O, Watemberg N. Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures［J］. J Child Neurol, 2007, 22（3）: 255-259. ［47］Hmaimess G, Kadhim H, Nassogne MC, Bonnier C, van Rijckevorsel K. Levetiracetam in a neonate with malignant migrating partial seizures［J］. Pediatr Neurol, 2006, 34（1）: 55-59. ［48］Silverstein FS, Ferriero DM. Off-label use of antiepileptic drugs for the treatment of neonatal seizures［J］. Pediatr Neurol, 2008, 39（2）: 77-79. ［49］Shoemaker MT, Rotenberg JS. Levetiracetam for the treatment of neonatal seizures［J］. J Child Neurol, 2007, 22（1）: 95-98. ［50］Kahle KT, Barnett SM, Sassower KC, Staley KJ. Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1［J］. J Child Neurol, 2009, 24（5）: 572-576. ［51］Flack S, Ojemann J, Haberkern C. Cerebral hemispherectomy in infants and young children［J］. Paediatr Anaesth, 2008, 18（10）: 967-973.