Levels of serum acylation-stimulating protein and C3 in children with primary nephrotic syndrome

WANG Jian-Jun; HUANG Yue; WU Chun; XU Yu-Xia; WEI Yu-Shu; ZHAO Yao

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (10) : 817-819.

CLINICAL RESEARCH

Levels of serum acylation-stimulating protein and C3 in children with primary nephrotic syndrome

WANG Jian-Jun, HUANG Yue, WU Chun, XU Yu-Xia, WEI Yu-Shu, ZHAO Yao

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Abstract

OBJECTIVE: To study serum acylation-stimulating protein (ASP) and complement 3 (C3) levels and their relationship with blood lipids in children with primary nephrotic syndrome (PNS). METHODS: Blood samples were obtained from 35 PNS children with proteinuria, 25 children with PNS at remission and 35 body mass index-matched healthy children (control group). Fasting serum ASP, C3, albumin and blood lipids were measured. RESULTS: The serum ASP levels in the proteinuria group (101±22 nmol/L) were significantly higher than those in the remission group (32±8 nmol/L) and the control group (33± 8 nmol/L) (P0.05). CONCLUSIONS: The increased serum ASP level may be associated with a complemental mechanism against hyperlipidemia in children with PNS.

Key words

Acylation-stimulating protein / Complement 3 / Blood lipid / Primary nephrotic syndrome / Child

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WANG Jian-Jun, HUANG Yue, WU Chun, XU Yu-Xia, WEI Yu-Shu, ZHAO Yao. Levels of serum acylation-stimulating protein and C3 in children with primary nephrotic syndrome[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(10): 817-819

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