Association between single nucleotide polymorphism of insulin-like growth factor receptor gene and idiopathic short stature

HUANG Hui; YANG Yu; WANG Wei; YANG Li; XIE Li-Ling; WANG Ying; WEI Hai-Yan

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (12) : 955-958.

Association between single nucleotide polymorphism of insulin-like growth factor receptor gene and idiopathic short stature

江西省儿童医院内分泌科，江西南昌330006

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Abstract

OBJECTIVE: To study the association between single nucleotide polymorphism (SNP) of insulin-like growth factor I receptor (IGF-IR) gene and idiopathic short stature (ISS). METHODS: A total of 804 children with ISS and 575 normal controls were recruited from 2008 to 2011. IGF-IR gene SNP was genotyped using the Snapshot Multiplex System. RESULTS: The distribution frequency of genotype rs1976667 showed no significant difference between the ISS and the control groups, while that of the allele A of rs1976667 was significantly higher in the ISS group than in the control group (P<0.01). CONCLUSIONS: The allele A at rs1976667 SNP of IGF-IR gene is a risk factor for ISS.

Key words

Idiopathic short stature / Insulin-like growth factor receptor / Single nucleotide polymorphism / Child

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HUANG Hui, YANG Yu, WANG Wei, YANG Li, XIE Li-Ling, WANG Ying, WEI Hai-Yan. Association between single nucleotide polymorphism of insulin-like growth factor receptor gene and idiopathic short stature[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(12): 955-958

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