P-selectin gene -2123 polymorphism in children with Henoch-Schonlein purpura

LI Jing; WANG Yi-Bing; LIU Hua-Lin; JIANG Yu-Hong; LIU Wei; WANG Ya-Qiu

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (4) : 278-281.

CLINICAL RESEARCH

P-selectin gene -2123 polymorphism in children with Henoch-Schonlein purpura

LI Jing, WANG Yi-Bing, LIU Hua-Lin, JIANG Yu-Hong, LIU Wei, WANG Ya-Qiu

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Abstract

OBJECTIVE: To investigate whether P-selectin gene -2123 polymorphism is associated with the pathogenesis of Henoch-Schonlein purpura (HSP) in children. METHODS: Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) is used to identify the distribution of allele and genotype frequencies of P-selectin gene promoter -2123 polymorphism in 86 children with HSP (including 40 cases of purpura nephritis) and 70 healthy controls. RESULTS: Compared with the healthy controls, the frequencies of GG genotype and G allele of P-selectin promoter -2123 in children with HSP increased significantly (P<0.05). There were no significant differences in P-selectin promoter -2123 genotype and allele frequencies between the patients with and without nephritis. CONCLUSIONS: P-selectin gene promoter -2123 polymorphism appears to be associated with the pathogenesis of HSP in children.

Key words

Henoch-Schonlein purpura / Nephritis / P-selectin / Gene polymorphism / Child

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LI Jing, WANG Yi-Bing, LIU Hua-Lin, JIANG Yu-Hong, LIU Wei, WANG Ya-Qiu. P-selectin gene -2123 polymorphism in children with Henoch-Schonlein purpura[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(4): 278-281

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