Clinical characteristics of human bocavirus infection in 90 children

YAN Hua-Jie, SHENG Jun, DONG Wei, SHAO Jie

Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (4) : 300-302.

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (4) : 300-302.
CLINICAL RESEARCH

Clinical characteristics of human bocavirus infection in 90 children

  • YAN Hua-Jie, SHENG Jun, DONG Wei, SHAO Jie
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Abstract

OBJECTIVE: To study the clinical characteristics of human bocavirus (HBoV) infection in children. METHODS: Nasal and throat swab samples were collected in 843 children with lower respiratory tract infection. The multiple RT-PCR method was used to detect HBoV and six other common respiratory tract viruses. The clinical characteristics of HboV positive cases were investigated. RESULTS: Among 843 cases, 90 were HboV positive (10.7%), 131 were respiratory syncytial virus (RSV) positive (15.5%), 117 were influenza virus positive (13.9%), 84 were parainfluenza virus positive (10.0%), 55 were rhinovirus positive (6.5%), 48 were coronavirus positive (5.7%), and 33 were human metapneumovirus positive (3.7%). Of the 90 HBoV infected patients, 45 (50%) showed a co-infection with other respiratory tract viruses. Among them, 33 were infected with one other type of virus (37%), 11 (12%) were infected with two other types of virus, and 1 case (1%) was infected with other three viruses. The HBoV positive rate in children with wheezing was significantly higher than those without wheezing (17.0% vs 9.2%; P<0.01). The common clinical manifestations of HBoV-infected patients included frequent coughing, wheezing and fever. There were no significant differences in the frequency of wheezing between HBoV and RSV infected patients. CONCLUSIONS: HBoV positive rate detected from children with wheezing is higher than from children without wheezing, suggesting that apart from RSV, HBoV is another virus causing wheezing in children with respiratory tract infection. Co-infections of HBoV with other respiratory track viruses can be present in some patients.

Key words

Human bocavirus / Lower respiratory track infection / Wheezing / Child

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YAN Hua-Jie, SHENG Jun, DONG Wei, SHAO Jie. Clinical characteristics of human bocavirus infection in 90 children[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(4): 300-302

References

[1]Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples[J]. Proc Natl Acad Sci USA, 2005, 102(36): 12891-12896.

[2]Allander T, Jartti T, Gupta S, Niesters HG, Lehtinen P, Osterback R, et al. Human bocavirus and acute wheezing in children[J]. Clin Infect Dis, 2007, 44(7): 904-910.

[3]Manning A, Russell V, Eastick K, Leadbetter GH, Hallam N, Templeton K, et al. Epidemiological profile and clinical assosciations of human bocavirus and other human parvoviruses[J]. J Infect Dis, 2006, 194(9): 1283-1290.

[4]胡亚美,江载芳. 诸福棠实用儿科学[M].第7版.北京:人民卫生出版社,2002:631-1199.

[5]陈倩,施圣云,胡正,张其华,曹新.南京地区急性呼吸道感染儿童支原体、衣原体和常见呼吸道病毒病原学分析[J].中国当代儿科杂志,2010,12(6):450-454.

[6]Weissbrich B, Neske F, Schubert J, Tollmann F, Blath K, Blessing K, et al. Frequent detection of bocavirus DNA in German children with respiratory tract infections[J].BMC Infect Dis, 2006, 6:109.

[7]Sloots TP, McErlean P, Speicher DJ, Arden KE, Nissen MD, Mackay IM. Evidence of human coronavirus HKU1 and human bocavirus in Australian children[J]. J Clin Virol,  2006, 35(1): 99-102.
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