Association of adiponectin gene polymorphism with obesity in children

WU Jing, YAN Wei-Jian, MO Juan, YANG Hao-Bo, WANG Zhao-Zhao, LEI Min-Xiang, PENG Lie-Wu

Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (7) : 539-542.

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (7) : 539-542.
CLINICAL RESEARCH

Association of adiponectin gene polymorphism with obesity in children

  • WU Jing, YAN Wei-Jian, MO Juan, YANG Hao-Bo, WANG Zhao-Zhao, LEI Min-Xiang, PENG Lie-Wu
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Abstract

OBJECTIVE: To study the distribution characteristics of adiponectin gene +45 single nucleotide polymorphisms (SNP) in Chinese children, and to determine the role of adiponectin gene +45 polymorphisms in the pathogenesis of childhood obesity. METHODS: A total of 147 Chinese obese and 118 healthy children were randomly selected and enrolled to identify adiponectin gene SNP+45 polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Plasma adiponectin levels were determined using ELISA. Waist circumference (WC), waist to hip ratio (WHR), percentage of body fat (%BF), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), serum triglycerides (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), plasma fasting insulin (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR) were measured. RESULTS: The allelic frequency of adiponectin gene SNP+45 in children with obesity and healthy controls were 40.5% and 25.4%, respectively. There were significant differences in the distribution of genotypes and the allelic frequency between the two groups (P<0.05). The plasma adiponectin levels were significantly higher, in contrast, %BF, HOMA-IR, TC and LDL-C levels were significantly lower in obese children with TT genotype than those in obese children with TG or GG genotype. CONCLUSIONS: The adiponectin gene SNP+45 polymorphism may be associated with pathogenesis of obesity in children. T→G variance may be associated an increased risk of childhood obesity and result in a decreased level of adiponectin.

Key words

Adiponectin / Single nucleotide polymorphisms / Obesity / Child

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WU Jing, YAN Wei-Jian, MO Juan, YANG Hao-Bo, WANG Zhao-Zhao, LEI Min-Xiang, PENG Lie-Wu. Association of adiponectin gene polymorphism with obesity in children[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(7): 539-542

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