OBJECTIVE: To study the roles of allergen testing in vitro and impulse oscillometry for lung function measurements in preschool children with cough variant asthma (CVA). METHODS: ethodsForty-four preschool children with acute asthma, 41 with chronic asthma, 46 with CVA, and 35 healthy preschool children as control were recruited in the study. Inhaled allergen, food allergen, and mite-specific IgE were determined by Pharmacia UniCAP System. Serum eosinophil cationic protein (ECP) and total IgE levels were measured. Lung function was assessed by impulse oscillometry. RESULTS: The positive rates of inhaled allergen and food allergen, and total IgE levels in the CVA, acute asthma and chronic asthma groups were higher than those in the control group (P<0.01). However, no significant differences were found among the three case groups. The serum ECP levels in the CVA group were lower than those in the acute asthma group (P<0.01), but did not show differences when compared with the chronic asthma group. The impulse oscillometry demonstrated that the respiratory total impedance (Zrs), airway resistance at 5 Hz (R5), airway resistance at 20 Hz (R20), subtracting R5 from R20 (R5-R20) and resonant frequency (Fres) in the CVA, acute asthma and chronic asthma groups were higher than those in the control group (P<0.01). Zrs, R5, R20, R5-R20, and Fres in the CVA and chronic asthma groups were lower than those in the acute asthma group (P<0.01). Serum ECP levels were positively correlated with Zrs, R5, R5-R20 and Fres (P<0.05) in the CVA and chronic asthma groups. CONCLUSIONS: The measurements of allergens, serum ECP and impulse oscillometry for lung function are helpful for the evaluation of airway inflammation and airway obstruction in preschool children with CVA.
Key words
Cough variant asthma /
Allergen testing in vitro /
Impulse oscillometry /
Eosinophil cationic protein /
Child
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
［1］Frei J, Jutla J, Kramer G, Hatzakis GE, Ducharme FM, Davis GM. Impulse oscillometry: reference values in children 100 to 150 cm in height and 3 to 10 years of age［J］. Chest, 2005,128(3):1266-1273.
［2］Bacharier LB, Boner A, Carlsen KH, Eigenmann PA, Frischer T, Gotz M, et al. Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report［J］. Allergy, 2008, 63(1): 5-34.
［3］中华医学会儿科学分会呼吸学组.儿童支气管哮喘诊断与防治指南［J］.中华儿科杂志, 2008,46(10):745-753.
［4］Oostveen E, MacLeod D, Lorino H, Farré R, Hantos Z, Desager K, et al. The forced oscillation technique in clinical practice: methodology, recommendations and future developments［J］. Eur Respir J, 2003, 22(6): 1026-1041.
［5］Matsumoto H, Niimi A, Tabuena RP, Takemura M, Ueda T, Yamaguchi M, et al. Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough［J］. Chest, 2007,131(4): 1042-1049.
［6］Mochizuki H, Arakawa H, Tokuyama K, Morikawa A. Bronchial sensitivity and bronchial reactivity in children with cough variant asthma［J］. Chest, 2005, 128(4): 2427-2434.
［7］Torrent M, Sunyer J, Garcia R, Harris J, Iturriaga MV, Puig C, et al. Early-life allergen exposure and atopy, asthma, and wheeze up to 6 years of age［J］. Am J Respir Crit Care Med, 2007,176(5):446-453.
［8］Wong CK, Lun SW, Ko FW, Ip WK, Hui DS, Lam CW. Increased expression of plasma and cell surface co-stimulatory molecules CTLA-4, CD28 and CD86 in adult patients with allergic asthma［J］. Clin Exp Immunol, 2005,141(1):122-129.
［9］Chu YT, Chiang W, Wang TN, Hung CH, Jong YJ, Wu JR. Changes in serum eotaxin and eosinophil cationic protein levels, and eosinophil count during treatment of childhood asthma［J］. J Microbiol Immunol Infect, 2007, 40(2): 162-167.
［10］吴婕翎,陈爱欢,彭秋莹,陈荣昌,钟南山. 哮喘儿童吸入糖皮质激素疗效与白三烯水平的相关性探讨［J］. 中国当代儿科杂志, 2009,11(6):441-444.
PDF(962 KB)
