Chromosome analysis in 92 children with congenital mental retardation

WANG Fang; YANG Yao; YANG Xiao; WANG Chun-Zhi; HE Xi-Yu

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (8) : 651-653.

CLINICAL RESEARCH

Chromosome analysis in 92 children with congenital mental retardation

WANG Fang, YANG Yao, YANG Xiao, WANG Chun-Zhi, HE Xi-Yu

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Abstract

OBJECTIVE: To explore the chromosome karyotypes in children with mental retardation. METHODS: The peripheral blood lymphocytes from 92 chidren with congenital mental retardation were cultured and analysed by the G-band technique. RESULTS: Of the 92 cases, 43 cases (47%) showed chromosome abnormalities. Autosomal abnormalities were found in 35 cases (38%) and sex chromosome abnormalities were found in 8 cases (9%). A novel abnormal karyotype 45,XX,psu dic（11;9）（p15;p24）was found in a child. CONCLUSIONS: Chromosome abnormalities may be important cytogenetic factors for congenital mental retardation. Cytogenetic chromosome karyotypic analysis appears to be an important method for genetic screening of congenital mental retardation.

Key words

Mental retardation / Chromosome karyotype / Child

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WANG Fang, YANG Yao, YANG Xiao, WANG Chun-Zhi, HE Xi-Yu. Chromosome analysis in 92 children with congenital mental retardation[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(8): 651-653

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