Risk factors for capillary leak syndrome in neonates

LI Yu-Mei, RAN Jie, LI Heng, YAN Chao-Ying

Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (9) : 708-710.

PDF(919 KB)
PDF(919 KB)
Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (9) : 708-710.
CLINICAL RESEARCH

Risk factors for capillary leak syndrome in neonates

  • LI Yu-Mei, RAN Jie, LI Heng, YAN Chao-Ying
Author information +
History +

Abstract

OBJECTIVE: To study the risk factors for capillary leak syndrome (CLS) in neonates. METHODS: The clinical data of 52 neonates with CLS (case group) were retrospectively reviewed. Fifty hospitalized neonates without CLS were used as the control group. The possible factors for the development of CLS were identified by univariate analysis. The independent risk factors for CLS were determined by multivariate logistic regression analysis. RESULTS: The univariate analysis showed that the incidences of hyperglycemia, respiratory distress syndrome (RDS), sepsis and cold injury syndrome in the case group were significantly higher than those in the control group (P<0.05). The logistic regression analysis showed that sepsis (OR=5.004, P=0.001), RDS (OR=3.880, P=0.013) and cold injury syndrome (OR=3.207, P=0.023) were the independent risk factors for the development of CLS. CONCLUSIONS: RDS, sepsis and cold injury syndrome are independent risk factors for CLS in neonates. Hyperglycemia may be associated with the development of CLS.

Key words

Capillary leak syndrome / Risk factor / Neonate

Cite this article

Download Citations
LI Yu-Mei, RAN Jie, LI Heng, YAN Chao-Ying. Risk factors for capillary leak syndrome in neonates[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(9): 708-710

References

[1]Marx G. Fluid therapy in sepsis with capillary leakage[J]. Eur J Anaesthesio1, 2003,20(6):429-442.

[2]Marx G, Vangerow B, Burczyk C, Gratz KF, Maassen N, Cobas Meyer M, et al. Evaluation of noninvasive determinants for capillary leakage syndrome in septic shock patients[J]. Intensive Care Med, 2000, 26(9): 1252-1258.

[3]Druey KM, Greipp PR. Narrative review: the systemic capillary leak syndrome[J]. Ann Intern Med, 2010, 153(2): 90-98.

[4]杨万杰. 毛细血管渗漏综合征临床研究进展[J]. 医学综述,2008,14(24):24-25.

[5]Hamacher J, Lucas R, Lijnen HR, Buschke S, Dunant Y, Wendel A, et al. Tumor necrosis factoralpha and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome[J]. Am J Respir Crit Care Med, 2002, 166(5): 651-656.

[6]Speziale G, Ferroni P, Ruvolo G, Fattouch K, Pulcinelli FM, Lenti L, et al. Effect of normothermic versus hypothermic cardiopulmonary bypass on cytokine production and platelet function[J]. J Cardiovasc Surg (Torino), 2000, 41(6):819-827.

[7]刘成军, 刘露, 许峰.小儿先天性心脏病体外循环术后毛细血管渗漏综合征的影响因素[J]. 中国实用儿科杂志, 2006,21(10):753-755.
PDF(919 KB)

Accesses

Citation

Detail

Sections
Recommended

/