Abstract OBJECTIVE: To study the effect of mouth-fed probiotics on pathogenic bacteria colonization of the oropharynx and lower respiratory tract in neonates undergoing mechanical ventilation. METHODS: Randomized control method was employed to divide the neonates undergoing mechanical ventilation into probiotics (n=82) and control groups (n=83). The control group received routine treatment. The probiotics group was administered with oral probiotics in addition to routine treatment. The number of pathogenic bacteria colonized on the oropharynx and lower respiratory tract, and the number of the bacterial strain of ventilator-associated pneumonia (VAP) in the two groups were examined. The timing of the bacteria colonization and VAP occurrence were also examined. RESULTS: The probiotics group presented a lower bacterial strain colonization rate of the oropharynx pathogenic bacteria than the control group (35% vs 51%; P<0.05). The colonization time of pathogenic bacteria of the oropharynx and lower respiratory tract, and the time of VAP occurrence lagged behind in the probiotics group compared with that the control group (P<0.05). No adverse reaction caused by probiotics was found. CONCLUSIONS: Probiotics administration is effective in decreasing pathogenic bacteria colonization on the oropharynx, in postponing the pathogenic bacteria colonization on the oropharynx and lower respiratory tract and in delaying the occurrence of VAP in neonates undergoing mechanical ventilation.
［1］Taveras EM, Rifas-Shiman SL, Belfort MB, Kleinman KP, Oken E, Gillman MW. Weight status in the first 6 months of life and obesity at 3 years of age［J］. Pediatrics, 2009, 123(4): 1177-1183.
［3］WHO Multicentre Growth Reference Study Group. WHO Child Growth Standards based on length/height, weight and age［J］. Acta Paediatr Suppl, 2006, 450: 76-85.
［4］Hesketh KD, Campbell KJ. Interventions to prevent obesity in 0-5 year olds: an updated systematic review of the literature［J］.Obesity (Silver Spring), 2010, 18(1): S27-S35.
［5］Whitaker RC. The infancy of obesity prevention［J］. Arch Pediatr Adolesc Med, 2010, 164(12): 1167-1169.
［8］Wang Y, Gao E, Wu J, Zhou J, Yang Q, Walker MC, et al. Fetal macrosomia and adolescence obesity: results from a longitudinal cohort study［J］. Int J Obes(Lond), 2009, 33(8): 923-928.
［9］Taveras EM, Rifas-Shiman SL, Sherry B, Oken E, Haines J, Kleinman K, et al. Crossing growth percentiles in infancy and risk of obesity in childhood［J］.Arch Pediatr Adolesc Med, 2011, 165(11): 993-998.
［10］Harrington JW, Nguyen VQ, Paulson JF, Garland R, Pasquinelli L, Lewis D. Identifying the"tipping point"age for overweight pediatric patients［J］. Clin Pediatr, 2010, 49(7): 638-643.
［11］Yu Z, Sun JQ, Haas JD, Gu Y, Li Z, Lin X. Macrosomia is associated with high weight-for-height in children aged 1-3 years in Shanghai, China［J］. Int J Obes(Lond), 2008, 32(1): 55-60.
［12］Mei Z, Grummer-Strawn LM, Scanlon KS. Does overweight in infancy persist through the preschool years? An analysis of CDC Pediatric Nutrition Surveillance System data［J］. Soz Praventivmed, 2003, 48(3): 161-167.
［14］Zhou LL, Sun QQ, Hu YQ, Liu JR, Liu SS, Zhang J, et al. Infant feeding practices and weight gain for length of term normal birth weight infants in the first 6 months of life［J］. J Clin Pediatr, 2010, 28 (10): 901-907.
