Effect of chorioamnionitis on brain injury in preterm infants

XU Li-Ping; REN Rong-Na; ZHU Shao-Bo; ZHUANG Hong-Mei; HUANG Zhong-Ling; YANG Hong

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Chinese Journal of Contemporary Pediatrics ›› 2012, Vol. 14 ›› Issue (09) : 661-663.

CLINICAL RESEARCH

Effect of chorioamnionitis on brain injury in preterm infants

XU Li-Ping, REN Rong-Na, ZHU Shao-Bo, ZHUANG Hong-Mei, HUANG Zhong-Ling, YANG Hong

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Abstract

OBJECTIVE: To explore the association between chorioamnionitis and brain injury in preterm infants. METHODS: A total of 88 preterm infants (28-34 weeks), who were born between June 2008 and June 2011, were divided into a case group (n=41) and a control group (n=47) according to whether or not they had chorioamnionitis. All the infants were examined by brain ultrasonography periodically after birth and underwent brain diffusion weighted imaging (DWI) between 3 and 7 days after birth. The two groups were compared in terms of the incidence of periventricular leukomalacia (PVL) and periventricular and intraventricular hemorrhage (PVH-IVH) by brain magnetic resonance imaging (MRI) at the corrected gestational age of 40 weeks. RESULTS: There was statistical significance in the incidence of PVL between the case and the control groups (32% vs 6%; P0.05). CONCLUSIONS: Chorioamnionitis is associated with brain injury in preterm infants, increasing the incidence of PVL but having little influence over the incidence of PVH-IVH.

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Chorioamnionitis / Brain injury / Preterm infant

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XU Li-Ping, REN Rong-Na, ZHU Shao-Bo, ZHUANG Hong-Mei, HUANG Zhong-Ling, YANG Hong. Effect of chorioamnionitis on brain injury in preterm infants[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(09): 661-663

References

［1］Pristauz G, Bauer M, Maurer-Fellbaum U, Rotky-Fast C, Bader AA, Haas J, et al. Neonatal outcome and two-years follow-up after expectant management of second trimester rupture of membranes［J］. Int J Gynecol Obstet, 2008, 101(3): 264-268.

［2］黄志恒，孙轶，陈超.早产儿脑病的研究现状［J］. 中国当代儿科杂志，2011,13（10）:771-775.

［3］赵志英，杨玲竹.绒毛膜羊膜炎诊断的研究进展［J］. 国际妇产科学杂志，2011，38（3）：207210.

［4］Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M, Berry SM. The fetal inflammatory response syndrome［J］. Am J Obstet Gynecol, 1998, 179(1): 194-202.

［5］陈惠金.努力提高我国早产儿脑损伤的诊断和防治水平［J］.临床儿科杂志，2006，24（3）：163-165.

［6］陈惠金.新生儿颅内病变的超声影像诊断与防治［M］.上海科技教育出版社，2006：31-33.

［7］Larroque B, Marret S, Ancel PY, Arnaud C, Marpeau L, Supernant K, et al. White matter damage and intraventricular hemorrhage in very preterm infants: the EPIPAGE study［J］. J Pediatr. 2003, 43(4): 447-483.

［8］尚云，刘玲，曹坤峰，王多德，王薇，许浩.宫内感染对早产新生大鼠脑发育的影响［J］. 中国当代儿科杂志，2010,12（7）:569572.

［9］Elllison VJ, Mocatta TJ, Winterbourn CC, Darlow BA, Volpe JJ, Inder TE. The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newborn［J］. Pediatr Res, 2006, 57(2): 282-286.

［10］Locatelli A, Ghidini A, Assi F, Andreani M, Malguzzi S, Paterlini G. Which factors affect the occurrence of severe cerebral lesions in preterm neonates who are born with intrauterine infection?［J］.Am J Obstet Gynecol, 2008, 199(4): 404.

［11］Suppiej A, Franzoi M, Vedovato S, Marucco A, Chiarelli S, Zanardo V. Neurodevelopmental outcome in preterm histological chorioamnionitis［J］. Early Hum Dev, 2009, 85(3): 187-189.

［12］中华医学会儿科学分会新生儿学组，早产儿脑损伤研究多中心协作组中国早产儿脑室内出血患病率的多中心调查3768例报告［J］.中华儿科杂志，2009，47(1): 5-11.

［13］Soraisham AS, Singhal N, McMillan DD, Sauve Rs, Lee SK; Canadian Neonatal Network. A multicenter study on the clinical outcome of chorioamnionitis in preterm infants［J］. Am J Obstet Gynecol, 2009, 200(4): 372.

［14］史学凯，农绍汉，高平明，吴时光，赵正云，罗晓鸿，等.胎盘组织炎症对早产儿脑室内出血发病风险的影响［J］.中国新生儿科杂志，2010，25（3）: 139-142.