Association of cytotoxic T lymphocyte-associated antigen-4+49A/G polymorphism with childhood type 1 diabetes mellitus: a meta-analysis

LUO Shu-Ying; TAN Li-Na; WEI Hai-Yan; ZHANG Yao-Dong; CHEN Yong-Xing

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Chinese Journal of Contemporary Pediatrics ›› 2012, Vol. 14 ›› Issue (09) : 683-688.

Association of cytotoxic T lymphocyte-associated antigen-4+49A/G polymorphism with childhood type 1 diabetes mellitus: a meta-analysis

LUO Shu-Ying, TAN Li-Na, WEI Hai-Yan, ZHANG Yao-Dong, CHEN Yong-Xing

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Abstract

OBJECTIVE: To evaluate the association of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) + 49A/G polymorphism with type 1 diabetes mellitus (T1DM) in children. METHODS: Papers about the association of CTLA4+49A/G polymorphism with T1DM in children were collected by searching PubMed, EBSCO, CBM, CNKI, and Wanfang Data. A meta-analysis was performed to examine differences in the genotypes (AG, GG, and GG+AG) and G allele at position 49 of the CTLA-4 gene between a childhood T1DM group and a control group. RESULTS: A total of 10 papers involving 1084 T1DM children and 1338 healthy children were included. The Meta-analysis was performed to evaluate the association of the genotypes (AG, GG, and GG+AG) and the G allele at position 49 of the CTLA-4 gene with T1DM using a fixed effect model according to the heterogeneity test results of all studies. The pooled OR values (95% CI) were 1.13 (0.97-1.33), 1.42 (1.16-1.75), 1.20 (1.03-1.40), and 1.21 (1.09-1.33), suggesting a significant difference in genotypes (AG, GG, and GG+AG) and the G allele at position 49 of the CTLA-4 gene between the two groups. CONCLUSIONS: CTLA-4 +49A/G polymorphism is associated with T1DM in children.

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Meta-analysis / Cytotoxic T lymphocyte-associated antigen-4 gene / Type 1 diabetes mellitus / Genetic polymorphism / Child

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LUO Shu-Ying, TAN Li-Na, WEI Hai-Yan, ZHANG Yao-Dong, CHEN Yong-Xing. Association of cytotoxic T lymphocyte-associated antigen-4+49A/G polymorphism with childhood type 1 diabetes mellitus: a meta-analysis[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(09): 683-688

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