Abstract OBJECTIVE: To study the value of anti-neutrophil cytoplasmic antibody (ANCA) in diagnosis of Kawasaki disease (KD). METHODS: Serum ANCA was detected in 30 children with typical Kawasaki disease (TKD) and in 16 with incomplete Kawasaki disease (IKD) in the acute and the recovery phases respectively. Twenty-five healthy children were randomly selected as a control group. An ultrasonic cardiography (UCG) was performed on children with KD in the acute phase. RESULTS: The mean positive rate of serum ANCA in the acute phase in KD children was 65%, with 69% in IKD children and 63% in TKD children, which were obviously higher than that in the control group (P＜0.01). The positive rate of serum ANCA in the recovery phase in KD children was significantly lower than that in the acute phase (33％ vs 65％, P＜0.05). The positive rate of serum ANCA in the acute phase in children with KD was significantly higher than that detected by UCG (P＜0.01). The incidence rate of coronary artery lesions in children with positive ANCA was obviously higher than that in children with negative ANCA (43％ vs 13％; P＜0.05). CONCLUSIONS: Serum ANCA may be used as a reference index for early diagnosis of KD and secondary coronary artery lesions in children.
JIANG Zhi-Gui,LIU Ling,YANG Cui-Yan et al. Value of anti-neutrophil cytoplasmic antibody in diagnosis of Kawasaki disease[J]. 中国当代儿科杂志, 2012, 14(1): 45-47.
JIANG Zhi-Gui,LIU Ling,YANG Cui-Yan et al. Value of anti-neutrophil cytoplasmic antibody in diagnosis of Kawasaki disease[J]. CJCP, 2012, 14(1): 45-47.
［1］Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association［J］. Pediatrics, 2004, 114(6): 1708-1733.
［6］Ayusawa M, Sonobe T, Uemura S, Ogawa S, Nakamura Y, Kiyosawa N, et al. Revision of diagnostic guidelines for Kawasadi disease (the 5th revised edition)［J］. Pediatr Int, 2005, 47(2): 232-234.
［8］Kobayashi T, Inoue Y, Takeuchi K, Okada Y, Tamura K, Tomomasa T, et al. Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease［J］. Circulation, 2006, 113(22): 2606-2612.
［9］Davies DJ,Moran JE,Niall JF,Ryan GB.Segmetal necrotising glomemlonephfitis with antineutrophil antibody：possible arboviras aetiology?［J］.Br Med J (Clin Res Ed), 1982, 285(6342): 606.
