Relationship between TIM-4 polymorphism and childhood asthma

CHEN Jian-Ping; ZHAO Wan-Ying; HE Nian-Hai; HE Shui-Xiang; WANG Gang; WANG Wan-Jun

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Chinese Journal of Contemporary Pediatrics ›› 2012, Vol. 14 ›› Issue (2) : 120-123.

CLINICAL RESEARCH

Relationship between TIM-4 polymorphism and childhood asthma

CHEN Jian-Ping, ZHAO Wan-Ying, HE Nian-Hai, HE Shui-Xiang, WANG Gang, WANG Wan-Jun

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Abstract

OBJECTIVE: To elucidate whether the polymorphism of asthma immune regulator gene TIM-4 is associated with the risk of childhood allergic asthma in the southwest region of China. METHODS: TIM-4 gene promoter region RS6882076 and intron RS4704727 were studied. PCR-RFLP was used to test the genotypes of two polymorphism loci among 579 cases (average 7.2 years old) of asthma and 524 controls (average 7.6 years old) in a case-control study. RESULTS: There were significant differences in the frequency of gene types at RS4704727 site between the asthma and the control groups (P0.05). CONCLUSIONS: RS4704727 polymorphism of TIM-4 gene may be associated with childhood asthma, providing a better understanding of the pathogenesis of childhood asthma in the Southwest region of China.

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Asthma / Single nucleotide polymorphism / TIM-4 / Child

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CHEN Jian-Ping, ZHAO Wan-Ying, HE Nian-Hai, HE Shui-Xiang, WANG Gang, WANG Wan-Jun. Relationship between TIM-4 polymorphism and childhood asthma[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(2): 120-123

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