儿童传染性单核细胞增多症与急性淋巴细胞白血病GST基因遗传多态性研究

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Abstract OBJECTIVE: To study the relationship between glutathione S-transferase genes GSTT1 and GSTM1 polymorphisms and the susceptibility to infectious mononucleosis (IM) and acute lymphocytic leukemia (ALL) in children. METHODS: The case-control study involved 106 children with IM, 41 children with ALL and a control group of 100 children with non-hematologic and nontumorous diseases. The genetic polymorphisms of GSTT1 and GSTM1 were detected with multiplex polymerase chain reaction (PCR). Distribution of the genotypes in the children was analyzed. RESULTS: The frequency of GSTT1 null genotype in children with IM was significantly higher than in the control group (P<0.05). The risk of IM in children carrying GSTT1 null genotype was 2.186 times higher than in those carrying GSTT1 non-null genotype. The children carrying both GSTT1 and GSTM1 null genotype had a higher risk of suffering from IM compared to those carrying only one of the null genotypes (OR=4.937). The frequency of GSTM1 null genotype in children with ALL was significantly higher than in the control group (P<0.05). The risk of ALL in children carrying GSTM1 null genotype was 2.242 times higher than in those in carrying GSTT1 non-null genotype. Children carrying both GSTT1 and GSTM1 null genotype had a higher risk of suffering from ALL compared with those carrying only one of the null genotypes (OR=8.552). CONCLUSIONS: Children carrying GSTT1 or GSTM1 null genotype have a high risk of suffering from IM or ALL. Still more increased susceptibility to IM or ALL may occur in children who carry both GSTT1 and GSTM1 null genotype. GSTT1 and GSTM1 might play a potential role in the pathogenesis of both IM and ALL.

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	LI Yu-Hua
	WEN Fei-Qiu
	XIAO Zhi-Hui
	CHEN Yi-Xin
	ZHANG Zhao-Xia
	CHEN Li-Li

Key words： Infectious mononucleosis Acute lymphoblastic leukemia Glutathione S-transferase gene Child

PACS:

R725

Cite this article:

LI Yu-Hua,WEN Fei-Qiu,XIAO Zhi-Hui et al. Genetic polymorphism of GST gene in children with infectious mononucleosis and acute lymphocytic leukemia[J]. 中国当代儿科杂志, 2012, 14(4): 260-263.

LI Yu-Hua,WEN Fei-Qiu,XIAO Zhi-Hui et al. Genetic polymorphism of GST gene in children with infectious mononucleosis and acute lymphocytic leukemia[J]. CJCP, 2012, 14(4): 260-263.

URL:

http://www.zgddek.com/EN/ OR http://www.zgddek.com/EN/Y2012/V14/I4/260

	［1］张朝霞，张轶庠，文飞球，陈亦欣，周克英. 儿童传染性单核细胞增多症患者GST基因遗传多态性的研究［J］. 中国现代医学杂志，2009，19(2)：227-230.
	［2］张利，王军，冯建飞，王宏，朱绍先，张欣欣. 谷胱甘肽S-转移酶M1／T1基因多态性与儿童急性淋巴白血病的相关性［J］. 实用儿科临床杂志，2008，23(3)：195-197.
	［3］宋东奎，邢东亮，张莉蓉，蒋欣，乔保平. 谷胱甘肽S-转移酶基因多态性与膀胱癌易感性关系［J］. 中华泌尿外科杂志，2008，29(2)：80-83.
	［4］李晓婷，袁燕莉，夏惜情，于宝柱，张铁娟，刘欧，等. 中国人群谷胱甘肽转移酶M1和T1的基因多态性分析：系统综述及吉林省结核涂阳人群研究［J］. 中华流行病学杂志，2009，30(5)：502-506.
	［5］任文博，范志亮，郭艳苏，李春岩，卜晖. 河北省健康人群谷胱甘肽硫转移酶T1、M1基因多态性的研［J］. 脑与神经疾病杂志，2009，17(2)：88-92.
	［6］Ye Z, Song H. Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis［J］. Eur J Cancer, 2005, 41(7): 980-989.
	［7］Garte S, Taioli E, Raimondi S, Paracchini V, Bincova B, Sram RJ, et al. Effects of metabolic genotypes on intermediary biomarders in subjects exposed to PAHS: resultes from the EXPAH study［J］. Mutat Res, 2007, 620(1-2): 7-15.
	［8］Weiserbs KF, Jacobson JS, Begg MD, Wang LW, Wang Q, Agrawal M, et al. A cross-sectional study of polycyclic aromatic hydrocarbon-DNA adducts and polymorphism of glutathione S-transferases among heavy smokers by race/ethnicity［J］. Biomarkers, 2003, 8(2): 142-155.
	［9］Chan JY, Ugrasena DG, Lum DW, Lu Y, Yeoh AE. Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children［J］. Hematol Oncol, 2011, 29(3): 116-123.