Impact of continuous blood purification on T cell subsets in children with severe sepsis

YUAN Yuan-Hong; XIAO Zheng-Hui; ZHANG Hui; FAN Jiang-Hua; ZHANG Xin-Ping; LU Xiu-Lan; XU Zhi-Yue; LUO Hai-Yan

doi:10.7499/j.issn.1008-8830.2014.02.020

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (2) : 194-197. DOI: 10.7499/j.issn.1008-8830.2014.02.020

Impact of continuous blood purification on T cell subsets in children with severe sepsis

YUAN Yuan-Hong¹, XIAO Zheng-Hui¹, ZHANG Hui², FAN Jiang-Hua¹, ZHANG Xin-Ping¹, LU Xiu-Lan¹, XU Zhi-Yue¹, LUO Hai-Yan¹

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Abstract

Objective To investigate the impact of continuous blood purification (CBP) on T-cell subsets and prognosis in children with severe sepsis. Methods A total of 42 children with severe sepsis were randomly divided into a control group (n=22) and a CBP group (n=20). The patients in the control group received conventional treatment, while those in the CBP group underwent continuous veno-venous hemofiltration daily 12-24 hours for 3 days besides conventional treatment. Changes in clinical variables and in peripheral blood regulatory T cell subsets were assessed 3 and 7 days after treatment. Results The pediatric intensive care unit length of stay and duration of mechanical ventilation were significantly shortened and the 28-day mortality rate was significantly lower in the CPB treatment group as compared with the control group (P<0.05). In the CBP treatment group, the percentage of CD3⁺, CD4⁺, CD8⁺ T cell populations and PCIS scores were significantly higher at 3 and 7 days after treatment than before treatment (P<0.05). At 7 days after treatment, the percentage of CD3⁺, CD4⁺, CD8⁺ T cell populations, CD4⁺/CD8⁺ ratio and PCIS scores were significantly higher in the CBP group than in the control group (P<0.05). Conclusions The CBP treatment may counteract the suppression of immune function and thus improve prognosis in children with severe sepsis.

Key words

Continuous blood purification / Sepsis / T lymphocytes / Pediatric critical illness score / Child

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YUAN Yuan-Hong, XIAO Zheng-Hui, ZHANG Hui, FAN Jiang-Hua, ZHANG Xin-Ping, LU Xiu-Lan, XU Zhi-Yue, LUO Hai-Yan. Impact of continuous blood purification on T cell subsets in children with severe sepsis[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(2): 194-197 https://doi.org/10.7499/j.issn.1008-8830.2014.02.020

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