Changes of plasma cardiotrophin-1 levels in neonates with myocardial ischemic injury

DIAO Yu-Qiao; JIANG Lian; ZHANG Hui-Fen; QU Fan; SHEN Ying; SHAO Qin

doi:10.7499/j.issn.1008-8830.2015.02.002

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Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (2) : 118-121. DOI: 10.7499/j.issn.1008-8830.2015.02.002

CLINICAL RESEARCH

Changes of plasma cardiotrophin-1 levels in neonates with myocardial ischemic injury

DIAO Yu-Qiao¹, JIANG Lian¹, ZHANG Hui-Fen¹, QU Fan¹, SHEN Ying¹, SHAO Qin²

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Abstract

Objective To study the changes and significance of plasma cardiotrophin-1 (CT-1) in neonates with hypoxic-ischemic encephalopathy (HIE) complicated by myocardial ischemic injury. Methods Forty-five neonates with HIE (15 mild cases, 24 moderate cases and 6 severe cases) were enrolled and divided into two subgroups based on the presence of myocardial injury (n=19) and not (n=26). Twenty healthy neonates were used as the control group. Plasma CT-1 levels were measured using double-antibody sandwich enzyme immunoassay method. Serum creatinine kinase MB (CK-MB) and cardiac troponin I (CTnI ) levels were also measured. Results Plasma CT-1 levels in the mild HIE (169±20 pg/mL) and moderate/severe HIE subgroups (287±44 pg/mL) were significantly higher than those in the control group (30±8 pg/mL), and plasma CT-1 levels were associated with the severity of HIE (P<0.01). Plasma CT-1 levels were positively correlated with serum CK-MB and CTnI levels in neonates with HIE in the acute phase (r=0.565 and 0.621 respectively; P<0.01). Plasma CT-1 levels in neonates with myocardial injury were significantly higher than those without myocardial injury (249 ±35 pg/mL vs 177±26 pg/mL; P<0.01). Plasma CT-1 levels were significantly reduced in neonates with myocardial injury in the convalescent phase (157±19 pg/mL) compared with those in the acute phase (249±35 pg/mL; P<0.01). Conclusions Detection of plasma CT-1 levels may be useful in the diagnosis of myocardial ischemic injury and the severity evaluation of HIE.

Key words

Cardiotrophin-1 / Hypoxic-ischemic encephalopathy / Myocardial injury / Neonate

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DIAO Yu-Qiao, JIANG Lian, ZHANG Hui-Fen, QU Fan, SHEN Ying, SHAO Qin. Changes of plasma cardiotrophin-1 levels in neonates with myocardial ischemic injury[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(2): 118-121 https://doi.org/10.7499/j.issn.1008-8830.2015.02.002

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