Efficacy and safety of imatinib for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia in children

GUO Ye; LIU Tian-Feng; RUAN Min; YANG Wen-Yu; CHEN Xiao-Juan; ZHANG Li; WANG Shu-Chun; LIU Fang; ZHANG Jia-Yuan; LIU Xiao-Ming; QI Ben-Quan; ZOU Yao; ZHU Xiao-Fan

doi:10.7499/j.issn.1008-8830.2015.08.012

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Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (8) : 819-824. DOI: 10.7499/j.issn.1008-8830.2015.08.012

CLINICAL RESEARCH

Efficacy and safety of imatinib for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia in children

GUO Ye, LIU Tian-Feng, RUAN Min, YANG Wen-Yu, CHEN Xiao-Juan, ZHANG Li, WANG Shu-Chun, LIU Fang, ZHANG Jia-Yuan, LIU Xiao-Ming, QI Ben-Quan, ZOU Yao, ZHU Xiao-Fan

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Abstract

Objective To study the efficacy and safety of Chinese Childhood Leukemia Group ALL 2008 (CCLG-ALL2008) protocol combined with tyrosine kinase inhibitor (TKI, imatinib) for the treatment of Philadelphia chromosome-positive (Ph⁺) acute lymphoblastic leukemia (ALL) in children. Methods The clinical data of 53 patients aged less than 15 years when first diagnosed with Ph⁺ ALL between October 2008 and December 2013 were retrospectively analyzed. The patients were assigned to two groups: HR (n=26) and HR+TKI (n=27). The HR group was treated with CCLG-ALL2008 protocol (for high-risk patients). The HR+TKI group was treated with imatinib in combination with CCLG-ALL2008 protocol (for high-risk patients). Results The complete remission rate and chemotherapy induction-related mortality rate in the TKI+HR and HR groups were 100% vs 75% and 0 vs 15%, respectively. The 3-year event-free survival (EFS) rate in the HR group was (6±5)%; the 5-year EFS rate of the TKI+HR group was (52±11)%. Compared with the HR group, the TKI+HR group had no increase in the toxic responses to chemotherapy and had a decrease in the infection rate during the induction period. Conclusions Application of imatinib significantly improves the clinical efficacy in children with Ph⁺ ALL and has good safety.

Key words

Imatinib / Philadelphia chromosome / Acute lymphoblastic leukemia / Child

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GUO Ye, LIU Tian-Feng, RUAN Min, YANG Wen-Yu, CHEN Xiao-Juan, ZHANG Li, WANG Shu-Chun, LIU Fang, ZHANG Jia-Yuan, LIU Xiao-Ming, QI Ben-Quan, ZOU Yao, ZHU Xiao-Fan. Efficacy and safety of imatinib for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia in children[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(8): 819-824 https://doi.org/10.7499/j.issn.1008-8830.2015.08.012

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