PDF(1230 KB)
Risk factors for poor prognosis in children with severe adenovirus pneumonia
HUANG Miao, LUO Rong, FU Zhou
Chinese Journal of Contemporary Pediatrics ›› 2017, Vol. 19 ›› Issue (2) : 159-162.
PDF(1230 KB)
PDF(1230 KB)
Risk factors for poor prognosis in children with severe adenovirus pneumonia
Objective To investigate the risk factors for poor prognosis of severe adenovirus pneumonia (SAP) in children. Methods The clinical data of 189 children with SAP were retrospectively analyzed. Univariate logistic regression analysis was performed to assess the risk factors for poor prognosis. Results The univariate logistic regression analysis showed that the patients with hemoglobin < 90 g/L, plasma albumin < 30 g/L, C-reactive protein > 30 mg/L, procalcitonin > 10 ng/mL, alanine aminotransferase > 100 U/L, or aspartate aminotransferase > 100 U/L had poor prognosis (P < 0.05), and that those with congenital dysplasia of the airway, acute respiratory distress syndrome, circulatory complications, electrolyte and acid-base disturbance, or more than three complications also had poor prognosis (P < 0.05). Conclusions Poor prognosis of severe adenovirus pneumonia in children is associated with anemia, low serum albumin, inflammatory response, concurrent multiple complications and underlying lung diseases.
Adenovirus / Severe pneumonia / Prognosis / Risk factor / Child
[1] Lee J,Choi EH,Lee HJ.Comprehensive serotyping and epidemiology of human adenovirus isolated from the respiratory tract of Korean children over 17 consecutive years (1991-2007)[J].J Med Virol,2010,82(4):624-631.
[2] Houng HS,Gong H,Kajon AE,et al.Genome sequences of Human adenovirus 14 isolates from mild respiratory cases and a fatal pneumonia,isolated during 2006-2007 epidemics in North America[J].Respir Res,2010,11(1):116.
[3] Kajon AE,Dickson LM,Metzgar D,et al.Outbreak of febrile respiratory illness associated with adenovirus 11a infection in a Singapore military training cAMP[J].J Clin Microbiol,2010,48(4):1438-1441.
[4] Metzgar D,Gibbins C,Hudson NR,et al.Evaluation of multiplex type-specific real-time PCR assays using the LightCycler and joint biological agent identification and diagnostic system platforms for detection and quantitation of adult human respiratory adenoviruses[J].J Clin Microbiol,2010,48(4):1397-1403.
[5] Ou ZY,Zeng QY,Wang FH,et al.Retrospective study of adenovirus in autopsied pulmonary tissue of pediatric fatal pneumonia in South China[J].BMC Infect Dis,2008,8(4):526-528.
[6] Berkley JA,Munywoki P,Ngama M,et al.Viral etiology of severe pneumonia among Kenyan infants and children[J].JAMA,2010,303(20):2051-2057.
[7] 中华医学会儿科学分会呼吸学组.儿童社区获得性肺炎管理指南(2013修订)(下)[J].中华儿科杂志,2013,51(11):856-862.
[8] Lynch JP,Fishbein M,Echavarria M.Adenovirus[J].Semin Respir Crit Care Med,2011,32(4):494-511.
[9] 刘爱良,黄英,杨洋,等.儿童重症腺病毒肺炎213例临床特征分析[J].临床儿科杂志,2013,31(8):726-729.
[10] 余莉,武志远,洪婕,等.儿童重症腺病毒肺炎的临床研究[J].现代生物医学进展,2016,16(19):3713-3716.
[11] Cheng JL,Peng CC,Chiu NC,et al.Risk factor analysis and molecular epidemiology of respiratory adenovirus infections among children in northern Taiwan,2009-2013[J/OL].J Microbiol Immunol Infect.(September 2015).http://dx.doi.org/10.1016/j.jmii.2015.08.006.
[12] 杜芳,黄英,舒畅,等.小儿重症腺病毒肺炎混合感染及高危因素分析[J].中国当代儿科杂志,2013,15(5):375-378.
[13] 罗力妍,饶花平,徐畅,等.儿童重症腺病毒肺炎危险因素分析[J].中国中西医结合儿科学,2014,6(6):549-550.
[14] Hwang SM,Park DE,Yang YI,et al.Outbreak of febrile respiratory illness caused by adenovirus at a South Korean military training facility:clinical and radiological characteristics of adenovirus pneumonia[J].Jpn J Infect Dis,2013,66(5):359-365.
[15] Lai CY,Lee CJ,Lu CY,et al.Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan,2010-2011[J].PLoS One,2013,8(1):1-7.
[16] Peled N,Nakar C,Huberman H,et al.Adenovirus infection in hospitalized immunocompetent children[J].Clin Pediatr (Phila),2004,43(3):223-229.
