Association between BIM gene and glucocorticoid resistance in children with acute lymphoblastic leukemia

XU Jin-Yun, LUO Jian-Ming

Chinese Journal of Contemporary Pediatrics ›› 2017, Vol. 19 ›› Issue (8) : 945-948.

PDF(1344 KB)
PDF(1344 KB)
Chinese Journal of Contemporary Pediatrics ›› 2017, Vol. 19 ›› Issue (8) : 945-948. DOI: 10.7499/j.issn.1008-8830.2017.08.018
REVIEW

Association between BIM gene and glucocorticoid resistance in children with acute lymphoblastic leukemia

  • XU Jin-Yun, LUO Jian-Ming
Author information +
History +

Abstract

Acute lymphoblastic leukemia (ALL) is the most common malignant hematological disease in childhood. Glucocorticoids are frequently used in the chemoradiotherapy regimen for ALL and can induce the apoptosis of ALL cells through several signaling pathways, but about 10% of ALL children have poor response to glucocorticoids. Studies have revealed that glucocorticoids induce the apoptosis of ALL cells by upregulating the expression of BIM gene, and BIM gene is associated with glucocorticoid resistance in childhood ALL. This article reviews the recent studies on glucocorticoid resistance in childhood ALL, especially the role of BIM and its expression products in this process.

Key words

BIM gene / Glucocorticoid / Acute lymphoblastic leukemia / Drug resistance / Child

Cite this article

Download Citations
XU Jin-Yun, LUO Jian-Ming. Association between BIM gene and glucocorticoid resistance in children with acute lymphoblastic leukemia[J]. Chinese Journal of Contemporary Pediatrics. 2017, 19(8): 945-948 https://doi.org/10.7499/j.issn.1008-8830.2017.08.018

References

null

PDF(1344 KB)

Accesses

Citation

Detail

Sections
Recommended

/