Expression and significance of endothelial microparticles in children with HenochSch&#246;nlein purpura

FU Shu-Qin; GUO Yan-Jun; SONG Chun-Lan

doi:10.7499/j.issn.1008-8830.2018.10.009

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Chinese Journal of Contemporary Pediatrics ›› 2018, Vol. 20 ›› Issue (10) : 831-834. DOI: 10.7499/j.issn.1008-8830.2018.10.009

CLINICAL RESEARCH

Expression and significance of endothelial microparticles in children with HenochSchönlein purpura

FU Shu-Qin, GUO Yan-Jun, SONG Chun-Lan

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Abstract

Objective To study the expression and significance of endothelial microparticles (EMPs) in children with Henoch-Schönlein purpura (HSP). Methods A total of 100 previously untreated children with HSP were classified to Henoch-Schönlein purpura nephritis (HSPN) group (n=40) and non-nephritis group (n=60). Thirty healthy children who underwent physical examination were enrolled as control group. Serum levels of EMPs, T helper 17 cells (Th17), and interleukin-17 (IL-17) were compared between groups. Results The HSPN and non-nephritis groups had significantly higher levels of Th17 and IL-17 than the control group, and the HSPN group had the highest levels (P < 0.05). The HSPN and non-nephritis groups had a significantly higher level of EMPs than the control group, and the HSPN group had the highest level (P < 0.05). In the HSPN group, the levels of Th17 and IL-17 were positively correlated with the level of EMPs (r=0.830 and 0.644 respectively; P < 0.05). Conclusions EMPs play an important role in the pathogenesis of HSP. The increase in EMPs might be one of the reasons for renal involvement in children with HSP.

Key words

Endothelial microparticle / Henoch-Schönlein purpura / Henoch-Schönlein purpura nephritis / Child

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FU Shu-Qin, GUO Yan-Jun, SONG Chun-Lan. Expression and significance of endothelial microparticles in children with HenochSchönlein purpura[J]. Chinese Journal of Contemporary Pediatrics. 2018, 20(10): 831-834 https://doi.org/10.7499/j.issn.1008-8830.2018.10.009

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