Abstract Objective To study heart rate variability (HRV) in neonates with non-benign tachyarrhythmia (NNTA) and the role of automatic nervous system (ANS) in NNTA. Methods The neonates who were admitted to the Department of Neonatology, the Second Xiangya Hospital of Central South University, from January 2010 to June 2018 and were diagnosed with NNTA were enrolled as the NNTA group, and the neonates with sinus rhythm or accidental premature beats on ambulatory electrocardiography were enrolled as the control group. Each group was further subdivided into preterm and term subgroups. A retrospective analysis was performed for their clinical data. Results A total of 27 NNTA neonates were enrolled, accounting for 0.28% (27/9 632) of all neonates hospitalized during the same period of time, and 53 neonates were enrolled in the control group. Compared with the preterm and term control subgroups, the preterm NNTA and term NNTA subgroups had a significant increase in the standard deviation of average RR interval (P Conclusions Immature and unbalanced ANS function may play an important role in the development and progression of NNTA.
Isik DU, Celik IH, Kavurt S, et al. A case series of neonatal arrhythmias[J]. J Matern Fetal Neonatal Med, 2016, 29(8):1344-1347.
[2]
Kundak AA, Dilli D, Karagöl B, et al. Non benign neonatal arrhythmias observed in a tertiary neonatal intensive care unit[J]. Indian J Pediatr, 2013, 80(7):555-559.
[3]
McMullen SL. Arrhythmias and cardiac bedside monitoring in the neonatal intensive care unit[J]. Crit Care Nurs Clin North Am, 2016, 28(3):373-386.
[4]
Franciosi S, Perry FKG, Roston TM, et al. The role of the autonomic nervous system in arrhythmias and sudden cardiac death[J]. Auton Neurosci, 2017, 205:1-11.
[5]
Yu L, Li X, Huang B, et al. Atrial fibrillation in acute obstructive sleep apnea:autonomic nervous mechanism and modulation[J]. J Am Heart Assoc, 2017, 6(9). pii:e006264.
[6]
Eyre EL, Duncan MJ, Birch SL, et al. The influence of age and weight status on cardiac autonomic control in healthy children:a review[J]. Auton Neurosci, 2014, 186:8-21.
[7]
Cardoso S, Silva MJ, Guimarães H. Autonomic nervous system in newborns:a review based on heart rate variability[J]. Childs Nerv Syst, 2017, 33(7):1053-1063.
[8]
Xhyheri B, Manfrini O, Mazzolini M, et al. Heart rate variability today[J]. Prog Cardiovasc Dis, 2012, 55(3):321-331.
[9]
Singh N, Moneghetti KJ, Christle JW, et al. Heart rate variability:an old metric with new meaning in the era of using mHealth technologies for health and exercise training guidance. Part one:physiology and methods[J]. Arrhythm Electrophysiol Rev, 2018, 7(3):193-198.
[10]
Ban JE. Neonatal arrhythmias:diagnosis, treatment, and clinical outcome[J]. Korean J Pediatr, 2017, 60(11):344-352.
[11]
Turner CJ, Wren C. The epidemiology of arrhythmia in infants:a population-based study[J]. J Paediatr Child Health, 2013, 49(4):278-281.
[12]
Southall DP, Johnson AM, Shinebourne EA, et al. Frequency and outcome of disorders of cardiac rhythm and conduction in a population of newborn infants[J]. Pediatrics, 1981, 68(1):58-66.
[13]
Sekarski N, Meijboom EJ, Di Bernardo S, et al. Perinatal arrhythmias[J]. Eur J Pediatr, 2014, 173(8):983-996.
[14]
Binnetoğlu FK, Babaoğlu K, Türker G, et al. Diagnosis, treatment and follow up of neonatal arrhythmias[J]. Cardiovasc J Afr, 2014, 25(2):58-62.
[15]
Golder V, Hepponstall M, Yiallourou SR, et al. Autonomic cardiovascular control in hypotensive critically ill preterm infants is impaired during the first days of life[J]. Early Hum Dev, 2013, 89(6):419-423.
[16]
Yiallourou SR, Witcombe NB, Sands SA, et al. The development of autonomic cardiovascular control is altered by preterm birth[J]. Early Hum Dev, 2013, 89(3):145-152.
[17]
Shaffer F, Ginsberg JP. An overview of heart rate variability metrics and norms[J]. Front Public Health, 2017, 5:258.
[18]
Lucchini M, Fifer WP, Sahni R, et al. Novel heart rate parameters for the assessment of autonomic nervous system function in premature infants[J]. Physiol Meas, 2016, 37(9):1436-1446.
[19]
Javorka K, Lehotska Z, Kozar M, et al. Heart rate variability in newborns[J]. Physiol Res, 2017, 66(Supplementum 2):S203-S214.
[20]
Jaeggi E, Öhman A. Fetal and neonatal arrhythmias[J]. Clin Perinatol, 2016, 43(1):99-112.
[21]
Huang WA, Boyle NG, Vaseghi M. Cardiac innervation and the autonomic nervous system in sudden cardiac death[J]. Card Electrophysiol Clin, 2017, 9(4):665-679.
[22]
Shen MJ, Zipes DP. Role of the autonomic nervous system in modulating cardiac arrhythmias[J]. Circ Res, 2014, 114(6):1004-1021.
[23]
Fyfe KL, Yiallourou SR, Wong FY, et al. The effect of gestational age at birth on post-term maturation of heart rate variability[J]. Sleep, 2015, 38(10):1635-1644.
[24]
Mulkey SB, Kota S, Swisher CB, et al. Autonomic nervous system depression at term in neurologically normal premature infants[J]. Early Hum Dev, 2018, 123:11-16.
[25]
Oliveira V, Martins R, Liow N, et al. Prognostic accuracy of heart rate variability analysis in neonatal encephalopathy:a systematic review[J]. Neonatology, 2019, 115(1):59-67.
[26]
Vergales BD, Zanelli SA, Matsumoto JA, et al. Depressed heart rate variability is associated with abnormal EEG, MRI, and death in neonates with hypoxic ischemic encephalopathy[J]. Am J Perinatol, 2014, 31(10):855-862.
[27]
Nguyen N, Vandenbroucke L, Hernández A, et al. Early-onset neonatal sepsis is associated with a high heart rate during automatically selected stationary periods[J]. Acta Paediatr, 2017, 106(5):749-754.
[28]
Lake DE, Fairchild KD, Moorman JR. Complex signals bioinformatics:evaluation of heart rate characteristics monitoring as a novel risk marker for neonatal sepsis[J]. J Clin Monit Comput, 2014, 28(4):329-339.
[29]
Hussein MA, Deng N, Rusin C, et al. Heart rate variability changes and its association with the development of severe retinopathy of prematurity[J]. J AAPOS, 2018, 22(5):371-375.
[30]
Özdemir R, Olukman Ö, Karadeniz C, et al. Effect of unconjugated hyperbilirubinemia on neonatal autonomic functions:evaluation by heart rate variability[J]. J Matern Fetal Neonatal Med, 2018, 31(20):2763-2769.
