Abstract Objective To study the value of autotaxin (an autocrine motility factor) level in serum and bronchoalveolar lavage fluid (BALF) in predicting refractory Mycoplasma pneumoniae pneumonia (RMPP) in children and its correlation with interleukin-6 (IL-6), interleukin-8 (IL-8), and C-reactive protein (CRP). Methods A retrospective analysis was performed on 238 children with Mycoplasma pneumoniae pneumonia who were admitted from January 2019 to December 2021. According to disease severity, they were divided into two groups: RMPP (n=82) and general Mycoplasma pneumoniae pneumonia (GMPP; n=156). The two groups were compared in terms of the levels of autotaxin, IL-6, IL-8, and CRP in serum and BALF to study the value of autotaxin level in serum and BALF in predicting RMPP in children, as well as the correlation of autotaxin level with IL-6, IL-8, and CRP in children with RMPP. Results Compared with the GMPP group, the RMPP group had significantly higher levels of autotaxin, IL-6, IL-8, and CRP in serum and BALF (P<0.05). For the children with RMPP, the levels of autotaxin, IL-6, IL-8, and CRP in serum and BALF in the acute stage were significantly higher than those in the convalescent stage (P<0.05). The receiver operating characteristic (ROC) curve showed that the level of autotaxin in serum and BALF had a good value in predicting RMPP in children, with an area under the curve of 0.874 (95%CI: 0.816-0.935) and 0.862 (95%CI: 0.802-0.924), respectively. The correlation analysis showed that the level of autotaxin in serum and BALF was positively correlated with IL-6, IL-8, and CRP levels (P<0.001). Conclusions The level of autotaxin in serum and BALF increases and is correlated with the degree of disease recovery and inflammatory cytokines in children with RMPP. Autotaxin can be used as a predictive indicator for RMPP in children.
FU Bin-Bin,ZHONG Lan-Lan,YE Ting-Ting et al. Value of autotaxin in predicting refractory Mycoplasma pneumoniae pneumonia in children and its correlation with inflammatory cytokines[J]. CJCP, 2022, 24(7): 765-770.
FU Bin-Bin,ZHONG Lan-Lan,YE Ting-Ting et al. Value of autotaxin in predicting refractory Mycoplasma pneumoniae pneumonia in children and its correlation with inflammatory cytokines[J]. CJCP, 2022, 24(7): 765-770.
Chen P, Huang Z, Chen L, et al. The relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory Mycoplasma pneumoniae pneumonia in children[J]. Sci Rep, 2021, 11(1): 2059. PMID: 33479472. PMCID: PMC7820231. DOI: 10.1038/s41598-021-81853-w.
Nikitopoulou I, Fanidis D, Ntatsoulis K, et al. Increased autotaxin levels in severe COVID-19, correlating with IL-6 levels, endothelial dysfunction biomarkers, and impaired functions of dendritic cells[J]. Int J Mol Sci, 2021, 22(18): 10006. PMID: 34576169. PMCID: PMC8469279. DOI: 10.3390/ijms221810006.
Gao L, Li X, Wang H, et al. Autotaxin levels in serum and bronchoalveolar lavage fluid are associated with inflammatory and fibrotic biomarkers and the clinical outcome in patients with acute respiratory distress syndrome[J]. J Intensive Care, 2021, 9(1): 44. PMID: 34130757. PMCID: PMC8207767. DOI: 10.1186/s40560-021-00559-3.
Xing H, Liu X, Li A, et al. Increased peripheral TFH cells and serum interleukin-21 in childhood Mycoplasma pneumoniae pneumonia[J]. J Coll Physicians Surg Pak, 2021, 30(5): 605-607. PMID: 34027881. DOI: 10.29271/jcpsp.2021.05.605.
Li J, Rong L, Cui R, et al. Dynamic changes in serum IL-6, IL-8, and IL-10 predict the outcome of ICU patients with severe COVID-19[J]. Ann Palliat Med, 2021, 10(4): 3706-3714. PMID: 33615814. DOI: 10.21037/apm-20-2134.
Ntatsoulis K, Karampitsakos T, Tsitoura E, et al. Commonalities between ARDS, pulmonary fibrosis and COVID-19: the potential of autotaxin as a therapeutic target[J]. Front Immunol, 2021, 12: 687397. PMID: 34671341. PMCID: PMC8522582. DOI: 10.3389/fimmu.2021.687397.
LIANG Wei-Ling, YE Xiao-Fan, ZHONG Gong, CHEN Jian-Jun, DAI Kang-Lin, CHEUK Ka Leung Daniel, MO Shu, WANG Bo-Shen, LI Chun-Yu, JIANG Xuan-Zhu, XU Zhi-Yuan, ZHOU Li, CHAN Irene, CHEN Jian-Liang, CHU Patrick., LEE Pui Wah Pamela, CHAN Chi Fung Godfrey. Clinical efficacy of combined therapy in children with stage 4 neuroblastoma[J]. CJCP, 2022, 24(7): 759-764.
Shaanxi Province Diagnosis and Treatment Center of Kawasaki Disease/Children's Hospital of Shaanxi ProvincialPeople's Hospital, Children's Hospital of Shanghai Jiao Tong University, Beijing Children's Hospital of Capital MedicalUniversity, Shengjing Hospital of China Medical University, Affiliated Hospital of Yan'an University, Expert Committeeof Advanced Training for Pediatrician, China Maternal and Children's Health Association, General Pediatric Group ofPediatrician Branch of Chinese Medical Doctor Association, Pediatric International Exchange and Cooperation Center,Shanghai Cooperation Organization Hospital Cooperation Alliance, Editorial Board of Chinese Journal ofContemporary Pediatrics. Pediatric expert consensus on the application of aspirin in Kawasaki disease[J]. CJCP, 2022, 24(6): 597-603.
